ArticleScientific reports2026
Clinicopathologic implications of sphingosine-1-phosphate pathway in extranodal NK/T-cell lymphoma according to immune subtype.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Extranodal NK/T-cell lymphoma (NKTL) is an aggressive lymphoma of mainly the natural killer (NK) cell lineage with Epstein–Barr virus infection. The clinicopathologic role of sphingosine-1-phosphate receptor 5 (S1PR5), a known player in NK cell trafficking, has not yet been investigated in NKTL. Herein, we explored the role of S1PR5 expression in NKTL according to immune subtype. A retrospective analysis of 64 patients with NKTL was performed based on immunohistochemical S1PR5 expression, immune subtypes and clinicopathologic variables. S1PR5 was highly expressed in 70% (45/64) of the NKTL patients. The S1PR5high group had lower levels of serum lactic dehydrogenase (LDH) (p = 0.012) than did the S1PR5low group, with tendencies toward a low/intermediate risk (0–1) of the prognostic index of NK cell lymphoma (PINK) and good ECOG performance status (ECOG PS; 0–1). Based on the 4 immune subtypes, immune evasion (IE)-A (n = 37) was the most common subtype with frequent LDH elevation (p = 0.005) and was subdivided by S1PR5 to produce the immune egress subtype (IES), i.e., immune tolerance (n = 2), IE-A-S1PR5high (n = 27), IE-A-S1PR5low (n = 10), IE-B (n = 12) and immune silenced (n = 13). According to the survival analysis, IES was associated with overall survival (OS) in the full cohort (p = 0.010). In addition, the S1PR5 expression was inversely correlated with the ECOG PS (p = 0.041) and predicted favorable OS in patients with the IE-A subtype (p = 0.014). S1PR5 may have a potential prognostic role in NKTL, especially for the IE-A subtype, which requires further validation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.