ArticleScientific reports2026
The patterns of acetylcholinesterases during developmental stages of Aedes aegypti and their susceptibility toward insecticides in egg stage.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
5 authors.
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Abstract
The screening of acetylcholinesterase (AChE) during developmental stages, eggs, larvae, pupa and adults of Aedes aegypti was detected. Chromatography on a Sephacryl S-200 column revealed two distinct peaks of acetylcholinesterases AChE1 and AChE2 in every developmental stage. The egg stage had the highest expression of AChE1 activity, which progressively declined throughout the larval, pupal, and adult stages. On the other hand, AChE2 activity was lowest in eggs and larvae, progressively increased in pupae, and peaked in adults. To avoid overlap with larval development, the properties of AChE1 and AChE2 from 36 h-old eggs were detected rather than 48 h-old eggs. The enzymes' substrate specificity revealed that, in comparison to acetylthiocholine iodide (AcSChI), the relative activity percentage for butyrylthiocholine iodide was 9.4 for AChE1 and 11.6 for AChE2. Ae. aegypti AChE1 and AChE2 had Km values of 0.256 and 0.288 mM AcSChI, respectively. The optimal pH and temperature for both enzymes were 7.5 and 40˚C, respectively. Up to 40˚C and 25˚C, respectively, the activity of AChE1 and AChE2 were thermally stable. With the exception of Co
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