ArticleNature communications2026
Digit regeneration in mice is stimulated by sequential treatment with FGF2 and BMP2.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
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Authors and funding
15 authors.
Funding
Abstract
Epimorphic regeneration in mice is stimulated at a non-regenerative digit amputation by sequential treatment with FGF2 and BMP2 (FGF2→BMP2). FGF2 stimulates digit amputation wound cells to form a blastema and BMP2 induces blastema differentiation to regenerate the amputated distal phalangeal element, albeit imperfectly. The formation of a phalangeal growth plate suggests that the induced regenerate recapitulates embryonic development and cell lineage studies show that wound cells that enter the blastema cells are positionally re-specified during regeneration. FGF2→BMP2 treatment also stimulates a blastema-independent response that regenerates a synovial joint complex containing stump-derived tendon, ligament and a sesamoid-like bone. Together the blastema-dependent and blastema-independent responses can result in the regeneration of all skeletal structures removed by amputation. The induced regeneration response demonstrates the availability of regeneration competent cells at a non-regenerating wound, and that FGF and BMP signaling is sufficient to trigger a regenerative outcome at wounds that heal by fibrosis.
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Registered trials
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