Evidence map›Paper›PMID 41997939›Full record

ArticleNature communications2026

γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response.

Anna Ruta, Kavita Krishnan, JiWon Woo, Joscelyn C Mejías, Elise F Gray-Gaillard, David R Maestas, Helen Hieu Nguyen, Alexandra N Rindone, Christopher Cherry, Michael Patatanian and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Recent advances in biomarkers for cardiac fibrosis.Frontiers in cardiovascular medicine · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Anna Ruta *Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Kavita Krishnan *Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.
JiWon WooTranslational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-9448-9051
Joscelyn C MejíasTranslational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Elise F Gray-GaillardDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-9832-6556
David R MaestasDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Helen Hieu NguyenTranslational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8015-5296
Alexandra N RindoneDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-2291-5933
Christopher CherryDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Michael PatatanianTranslational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Frank Haoning YuDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-2543-3702
Brenda YangDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Connor AmelungDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Christina D KingBuck Institute for Research on Aging, Novato, CA, USA.
Birgit SchillingBuck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0001-9907-2749
Sharon GerechtDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-8542-4835
Elana J FertigInstitute for Genome Science, University of Maryland School of Medicine, Baltimore, MD, USA.
Locke Davenport HuyerDepartment of Biomaterials & Applied Oral Sciences, Dalhousie University, Halifax, NS, Canada.ORCID http://orcid.org/0000-0003-1526-7122
Drew M PardollBloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-6215-1013
Jennifer H ElisseeffDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA. jhe@jhu.edu.ORCID http://orcid.org/0000-0002-5066-1996

Funding

Senescent cell mapping, identification and validation for human somatic and reproductive tissuesU54AG075932 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI Simon Melov, Birgit Schilling · 2021 to 2026
$12.5M
Biomaterials-directed regenerative immunotherapiesDP1AR076959 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ELISSEEFF, JENNIFER H · 2019 to 2023
$5.7M
National Science Foundation (NSF) DGE1746891National Science Foundation (NSF) DGE2139757NIA NIH HHS U54 AG075932U.S. Department of Health & Human Services | National Institutes of Health (NIH) DP1AR076959
6 · The paper itself

Abstract

Immune-stromal crosstalk governs tissue fibrosis, which is marked by dysregulated extracellular matrix (ECM) production and aberrant vasculature. Here, we investigate how γδ T cell interactions with stromal cells shape fibrosis in the foreign body response in a murine biomaterial implant model. During the acute reaction, type-1 (γδIFNγ) and type-17 (γδ17) γδ T cell subsets accumulate at the implant site. While γδIFNγ cells decrease as fibrosis progresses, activated γδ17 cells persist as dominant interleukin-17 producers. The γδ17 cell compartment expands with aging and high-fat diet, both factors associated with chronic inflammation and fibrosis. Fibroblasts co-cultured with γδ17 cells exhibit increased expression of collagen genes and intercellular communication inference links γδ T cell ligands to activation of ECM remodeling and vascular development programs in fibroblasts and endothelial cells. Finally, genetic deletion of γδ T cells in mice alters expression of ECM components and increases vessel size within the fibrotic matrix. Altogether, our findings implicate γδ T cells in regulating stromal cell behavior to modulate composition and vascularity of fibrotic tissues.

Indexed as

Extracellular MatrixForeign-Body ReactionIntraepithelial LymphocytesReceptors, Antigen, T-Cell, gamma-deltaStromal CellsAnimalsCell CommunicationCoculture TechniquesCollagenEndothelial CellsFibroblastsFibrosisInterleukin-17MaleMiceMice, Inbred C57BLCollagenInterleukin-17Receptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID41997939
PMCPMC13272810

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.