Evidence map›Paper›PMID 41997917›Full record

ArticleCell death & disease2026

Dedifferentiation-driven oncogenic stemness promotes tumor-sustaining adaptability in the intestinal epithelium.

Kylee Zgeib, Thompson Hui, Simon Garcia, Zahra Hashemi, Shima Nejati, Amartya Singh, Atharva Inamdar, Crystal Lim, Dahlia Matouba, Christina Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kylee Zgeib *Stevens Institute of Technology, Hoboken, NJ, USA.
Thompson Hui *Stevens Institute of Technology, Hoboken, NJ, USA.ORCID http://orcid.org/0000-0002-0408-055X
Simon GarciaStevens Institute of Technology, Hoboken, NJ, USA.
Zahra HashemiStevens Institute of Technology, Hoboken, NJ, USA.
Shima NejatiStevens Institute of Technology, Hoboken, NJ, USA.
Amartya SinghRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Atharva InamdarHackensack Meridian Health Center for Discovery and Innovation (CDI), Nutley, NJ, USA.
Crystal LimStevens Institute of Technology, Hoboken, NJ, USA.
Dahlia MatoubaStevens Institute of Technology, Hoboken, NJ, USA.
Christina LiStevens Institute of Technology, Hoboken, NJ, USA.
Binfeng LuHackensack Meridian Health Center for Discovery and Innovation (CDI), Nutley, NJ, USA.ORCID http://orcid.org/0000-0002-7822-5950
Ansu O PerekattStevens Institute of Technology, Hoboken, NJ, USA. aperekat@stevens.edu.ORCID http://orcid.org/0000-0003-3083-8405

Funding

Study of the IL-33-driven immune cell organization underpinning responses to immune checkpoint blockade cancer therapyR01CA254274 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LU, BINFENG · 2021 to 2025
$1.9M
Transcriptional regulation of oncogenic cellular plasticity in the intestinal epitheliumK22CA218462 · NCI · THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY · PI PEREKATT, ANSU · 2018 to 2020
$486k
NCI NIH HHS K22 CA218462U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) K22ACTFCA218462U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA254274
6 · The paper itself

Abstract

Intestinal tumorigenesis can occur via two distinct routes: bottom-up tumorigenesis occurs from mutations sustained in the Lgr5⁺ stem cells, whereas top-down tumorigenesis is driven by dedifferentiation of epithelial cells near the intestinal lumen. While sporadic human colon adenomas exhibit features of top-down tumorigenesis, their biological determinants remain elusive. Here, using a Smad4 loss-of-function and β-catenin gain-of-function (Smad4

Indexed as

Cell DedifferentiationIntestinal MucosaNeoplastic Stem CellsAnimalsbeta CateninCarcinogenesisCell ProliferationCell Transformation, NeoplasticHumansMiceReceptors, G-Protein-CoupledReceptors, NotchSignal Transductionbeta CateninReceptors, G-Protein-CoupledReceptors, Notch

Identifiers

PMID41997917
PMCPMC13216273

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.