ArticleNature communications2026
TMS5-mediated R-loop dynamics regulate thermosensitive fertility conversion in rice.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Innovations in hybrid rice seed production: Integrating agronomy, mechanization, and biotechnology.Plant communications · 2026Review
- TMS5-mediated R-loop dynamics regulate thermosensitive fertility conversion in rice.Nature communications · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Hybrid rice is vital for global food security, with the thermosensitive genic male sterility (TGMS) locus tms5 used in over 95% of the two-line breeding system. Despite its widespread application, the regulatory mechanism underlying tms5-mediated TGMS remains unclear. This study demonstrates that under high-temperature conditions, weakened tapetum function and delayed microspore mother cell development lead to pollen defects and male sterility, whereas under low-temperature conditions, tapetal function is restored and microspore mother cell development proceeds normally, allowing fertility comparable to wild-type Zhonghua11 (ZH11). We further reveal that the knockout of TMS5, which encodes an RNase enzyme, leads to significant accumulation of R-loops under high-temperature conditions, compromising genomic stability and causing pollen abortion. This R-loop accumulation correlates with fertility conversion, as R-loop levels are elevated in tms5 at high temperatures when plants show male sterility, but return to ZH11-comparable levels at low temperatures when fertility is restored. Overexpression of the R-loop resolving protein Local Lesions 1 (OsLS1) partially restores tms5 fertility, further supporting a direct role of R-loop dynamics in tms5 fertility. Our findings elucidate the cellular and molecular mechanisms of tms5-mediated TGMS and provide a basis for improving two-line hybrid rice breeding.
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Registered trials
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