Evidence map›Paper›PMID 41997545›Full record

ArticleBioorganic & medicinal chemistry letters2026

Investigating substituted phenylacetamide ligands in the D

Tian Li, Mohammad Alkhatib, Peter A Ramdhan, Lindsay Bourn, Jane K Rainwater, Norman Nguyen, Caitlin P Farrington, Blake Lewis, Chenglong Li, Thomas M Keck and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tian LiDepartment of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, NC 27268, United States.
Mohammad AlkhatibDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, United States.
Peter A RamdhanDepartment of Medicinal Chemistry, University of Florida College of Pharmacy, 1345 Center Drive, Gainesville, FL 32610, United States.
Lindsay BournDepartment of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, NC 27268, United States.
Jane K RainwaterDepartment of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, NC 27268, United States.
Norman NguyenDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, United States.
Caitlin P FarringtonDepartment of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, NC 27268, United States.
Blake LewisDepartment of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, NC 27268, United States.
Chenglong LiDepartment of Medicinal Chemistry, University of Florida College of Pharmacy, 1345 Center Drive, Gainesville, FL 32610, United States.
Thomas M KeckDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, United States.
Comfort A BoatengDepartment of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, NC 27268, United States. Electronic address: cboateng@highpoint.edu.

Funding

Development of High-Affinity and Selective Ligands as a Pharmacological Tool for the Dopamine D4 Receptor (D4R) Subtype VariantsDP1DA058385 · NIDA · HIGH POINT UNIVERSITY · PI Comfort Ahenkan Boateng · 2023 to 2026
$1.8M
NIDA NIH HHS DP1 DA058385
6 · The paper itself

Abstract

Preclinical studies indicate that selective targeting of D

Indexed as

AcetamidesBenzeneacetamidesReceptors, Dopamine D4AnimalsBinding SitesDose-Response Relationship, DrugHumansLigandsMolecular StructureStructure-Activity RelationshipAcetamidesBenzeneacetamidesLigandsReceptors, Dopamine D4Alkyl chainBicyclicDopamine D(4) receptorMolecular dynamicsPhenylpiperazine

Identifiers

PMID41997545
PMCPMC13575890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.