Evidence map›Paper›PMID 41997140›Full record

ArticleCell reports. Medicine2026

A dual-adjuvanted HA stem nanoparticle vaccine elicits a multifunctional antibody response that is associated with protection in newborn monkeys.

Kali F Crofts, Beth C Holbrook, Courtney L Page, Colby J Hendrix, David Caudell, Rebecca A Gillespie, Ralph B D'Agostino, Syed M Moin, Maya Sangesland, David A Ornelles and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kali F CroftsDepartment of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Beth C HolbrookDepartment of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Courtney L PageDepartment of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Colby J HendrixDepartment of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
David CaudellDepartment of Internal Medicine Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Rebecca A GillespieVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ralph B D'AgostinoDepartment of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Syed M MoinVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Maya SangeslandVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
David A OrnellesDepartment of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Masaru KanekiyoVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Martha A Alexander-MillerDepartment of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA. Electronic address: martha.alexander-miller@wfusm.edu.

Funding

TRAINING PROGRAM IN IMMUNOLOGY AND PATHOGENESIST32AI007401 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Martha Ann Alexander-Miller · 1991 to 2026
$4.4M
Development of vaccine approaches to elicit broadly protective influenza-specific immune responses in infantsR01AI146059 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALEXANDER-MILLER, MARTHA ANN · 2020 to 2024
$3.0M
Vaccination strategies to overcome immune deficiencies in neonatesR01AI098339 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALEXANDER-MILLER, MARTHA ANN · 2012 to 2015
$2.3M
NIAID NIH HHS R01 AI098339NIAID NIH HHS R01 AI146059NIAID NIH HHS T32 AI007401
6 · The paper itself

Abstract

The absence of an approved influenza vaccine for young infants, combined with the annual requirement for updates, underscores the urgent need for a universal vaccine that is effective in newborns. The H1ssF vaccine, an influenza hemagglutinin stem-bearing nanoparticle, generates broadly protective responses in adult animal models and humans. Here, we use a nonhuman primate model to explore the ability of H1ssF, adjuvanted with R848 and AddaVax, to induce a protective response in the altered immune setting of newborns. We find that the vaccine induces strong stem-specific IgG responses that are broadly reactive. Notably, the vaccine promotes antibodies with neutralizing activity and broad Fc effector functions in all newborns. Finally, administration of this vaccine confers improved viral clearance after challenge. These findings demonstrate the potential of this dual-adjuvanted stem nanoparticle to serve as an effective vaccine approach that can elicit protective responses in newborns against influenza A virus infection.

Indexed as

Adjuvants, ImmunologicAdjuvants, VaccineAntibody FormationHemagglutinin Glycoproteins, Influenza VirusInfluenza VaccinesNanoparticlesOrthomyxoviridae InfectionsAnimalsAnimals, NewbornAntibodies, NeutralizingAntibodies, ViralFemaleHumansImmunoglobulin GMacaca mulattaNanovaccinesAdjuvants, ImmunologicAdjuvants, VaccineAntibodies, NeutralizingAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusImmunoglobulin GInfluenza VaccinesNanovaccinesadjuvantsbroadly reactive antibodiesinfluenza hemagglutinin steminfluenza vaccinenanoparticle vaccinenewborn immunitynonhuman primatesTLR7/8 agonistuniversal vaccine

Identifiers

PMID41997140
PMCPMC13198238

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.