Evidence map›Paper›PMID 41996933›Full record

ArticleRedox biology2026

Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans.

Marina Valenzuela-Villatoro, Patricia de la Cruz-Ruiz, David Guerrero-Gómez, Eva Gómez-Orte, Alfonso Schiavi, Silvia Maglioni, Mayte Montero, Rosalba I Fonteriz, José Carlos Casas-Martínez, Nicole E Briand and 15 more

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Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Marina Valenzuela-VillatoroRedox Homeostasis Group, Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Patricia de la Cruz-RuizRedox Homeostasis Group, Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
David Guerrero-GómezRedox Homeostasis Group, Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Eva Gómez-OrteCentro de Investigación Biomédica de la Rioja (CIBIR), Logroño, La Rioja, Spain.
Alfonso SchiaviIUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany; Institute for Clinical Chemistry and Laboratory Diagnostic, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
Silvia MaglioniIUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany; Institute for Clinical Chemistry and Laboratory Diagnostic, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
Mayte MonteroDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, Valladolid, Spain; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), Valladolid, Spain.
Rosalba I FonterizDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, Valladolid, Spain; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), Valladolid, Spain.
José Carlos Casas-MartínezDiscipline of Physiology, School of Pharmacy and Medical Sciences, University of Galway, Galway, Ireland; Apoptosis Research Centre, University of Galway, Galway, Ireland; Galway RNA Research Cluster, University of Galway, Galway, Ireland.
Nicole E BriandDepartment of Microbiology, UMass Chan Medical School, Worcester, MA, USA.
Jingxiu XuInternational Biomedicine-X Research Center of the Second Affiliated Hospital, Zhejiang University School of Medicine and the Zhejiang University-University of Edinburgh Institute, Haining, Zhejiang, China; Center for Stem Cell and Regenerative Medicine and Department of Burn and Wound Repair of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
María Jesús Rodriguez-PaleroAndalusian Centre for Developmental Biology, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Pablo de Olavide, Junta de Andalucía, Department of Molecular Biology and Biochemical Engineering, Avenida Rectora Rosario Valpuesta 1, Dos Hermanas, Seville, Spain; Departamento de Biociencias, Facultad de Ciencias de la Salud, Universidad Loyola Andalucía, Avda. de las Universidades s/n, Dos Hermanas, Sevilla, Spain.
Marta Artal-SanzAndalusian Centre for Developmental Biology, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Pablo de Olavide, Junta de Andalucía, Department of Molecular Biology and Biochemical Engineering, Avenida Rectora Rosario Valpuesta 1, Dos Hermanas, Seville, Spain.
Katarzyna OlekLaboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland.
Justyna PolaczykLaboratory of Animal Molecular Physiology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Michal TurekLaboratory of Animal Molecular Physiology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Wojciech PokrzywaLaboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland.
Suhong XuInternational Biomedicine-X Research Center of the Second Affiliated Hospital, Zhejiang University School of Medicine and the Zhejiang University-University of Edinburgh Institute, Haining, Zhejiang, China; Center for Stem Cell and Regenerative Medicine and Department of Burn and Wound Repair of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Javier E IrazoquiDepartment of Microbiology, UMass Chan Medical School, Worcester, MA, USA.
Brian McDonaghDiscipline of Physiology, School of Pharmacy and Medical Sciences, University of Galway, Galway, Ireland; Apoptosis Research Centre, University of Galway, Galway, Ireland; Galway RNA Research Cluster, University of Galway, Galway, Ireland.
Javier ÁlvarezDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, Valladolid, Spain; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), Valladolid, Spain.
María OlmedoDepartamento de Genética, Facultad de Biología, Universidad de Sevilla, Avenida Reina Mercedes s/n, Seville, Spain.
Natascia VenturaIUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany; Institute for Clinical Chemistry and Laboratory Diagnostic, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany; Institute of Cell Biology, Heinrich Heine University Duesseldorf, Universitaetsstrasse 1, Duesseldorf, Germany; Department for the Promotion of Human Science and Quality of Life, University of Rome San Raffaele, Via di Val Cannuta 247, Rome, Italy.
Juan CabelloCentro de Investigación Biomédica de la Rioja (CIBIR), Logroño, La Rioja, Spain.
Antonio Miranda-VizueteRedox Homeostasis Group, Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. Electronic address: amiranda-ibis@us.es.

Funding

Mechanisms of the gut-brain axis that regulate innate immunityR35GM149284 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Javier Elbio Irazoqui · 2023 to 2026
$1.7M
FLAVIN-CONTAINING MONO-OXYGENASES AS NOVEL INNATE IMMUNITY EFFECTORSR21AI169842 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IRAZOQUI, JAVIER ELBIO · 2023 to 2024
$461k
NIAID NIH HHS R21 AI169842NIGMS NIH HHS R35 GM149284
6 · The paper itself

Abstract

Mitochondrial redox homeostasis is essential for cellular metabolism and organismal development. To investigate the consequences of disrupting redox homeostasis in this organelle in a metazoan organism, we generated a double mutant lacking mitochondrial glutathione reductase (gsr-1a) and thioredoxin reductase (trxr-2) genes in Caenorhabditis elegans. While gsr-1a or trxr-2 single mutants are phenotypically normal, double gsr-1a trxr-2 mutants displayed small body size, gonadal migration defects, reduced brood size, and prolonged egg-laying period, without developmental delay or lethality. Transcriptomic analysis revealed strong induction of ATFS-1-dependent stress and detoxification genes. Consistent with this, gsr-1a trxr-2 worms exhibited constitutive ATFS-1 nuclear localization and robust Phsp-6::gfp expression. Triple gsr-1a trxr-2; atfs-1 mutants were nonviable, demonstrating that unfolded protein response (UPR

Indexed as

Caenorhabditis elegansGerm CellsMitochondriaStress, PhysiologicalAnimalsCaenorhabditis elegans ProteinsGlutathione ReductaseHomeostasisMutationOxidation-ReductionOxidative StressReactive Oxygen SpeciesThioredoxin Reductase 2Transcription FactorsUnfolded Protein ResponseATFS-1 protein, C elegansCaenorhabditis elegans ProteinsGlutathione ReductaseReactive Oxygen SpeciesThioredoxin Reductase 2Transcription FactorsATFS-1ElegansGlutathione reductaseMitochondriaThioredoxin reductaseUnfolded protein response

Identifiers

PMID41996933
PMCPMC13099523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.