Evidence map›Paper›PMID 41996621›Full record

ArticleChemistry & biodiversity2026

In Silico and In Vitro Antiurolithic Effect of Extracts, Fractions, and Isolated Compounds From Eugenia mattosii.

Bianca Letícia Maciél, Luma Da Silva Portella, Camile Cecconi Cechinel-Zanchett, Anelize Dada, Rita de Cássia Vilhena da Silva, Anelise Felício Macarini, Valdir Cechinel Filho, Priscila de Souza, Giovana Vechi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bianca Letícia MaciélNutrition Department, Universidade do Vale do Itajaí UNIVALI, Santa Catarina, Brazil.
Luma Da Silva PortellaNutrition Department, Universidade do Vale do Itajaí UNIVALI, Santa Catarina, Brazil.
Camile Cecconi Cechinel-ZanchettNutrition Department, Universidade do Vale do Itajaí UNIVALI, Santa Catarina, Brazil.
Anelize DadaPharmaceutical Sciences, Universidade Do Vale do Itajaí UNIVALI, Itajaí, Brazil.
Rita de Cássia Vilhena da SilvaPharmaceutical Sciences, Universidade Do Vale do Itajaí UNIVALI, Itajaí, Brazil.
Anelise Felício MacariniPharmaceutical Sciences, Universidade Do Vale do Itajaí UNIVALI, Itajaí, Brazil.
Valdir Cechinel FilhoPharmaceutical Sciences, Universidade Do Vale do Itajaí UNIVALI, Itajaí, Brazil.
Priscila de SouzaPharmaceutical Sciences, Universidade Do Vale do Itajaí UNIVALI, Itajaí, Brazil.ORCID https://orcid.org/0000-0002-5251-5642
Giovana VechiNutrition Department, Universidade do Vale do Itajaí UNIVALI, Santa Catarina, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES)
6 · The paper itself

Abstract

Urolithiasis, a condition characterized by the formation of calcium oxalate stones in the urinary tract, remains a significant clinical challenge due to the limited availability of effective preventive therapies. This study investigated the antiurolithic potential of different preparations from Eugenia mattosii, a plant rich in phenolic constituents. Calcium oxalate (CaOx) precipitation was induced in rat urine samples. Potassium citrate (10 mg/mL) was used as the positive control, while the crude methanolic extract (CME), chloroform fraction (CLF), ethyl acetate fraction (EAF), pinostrobin (PIN), and cryptostrobin (CRY) were tested at concentrations ranging from 0.01 to 1 mg/mL. CME and EAF increased CaOx crystal formation, whereas CLF, PIN, and CRY significantly reduced crystal formation at 0.01 mg/mL. In silico ADMET analysis supported favorable pharmacokinetic and safety profiles for PIN and CRY. Molecular docking revealed strong interactions with MMP-9, suggesting a potential inhibitory effect that may reduce tissue injury and crystal nucleation. Overall, CLF and its flavonoids demonstrate promising antiurolithic activity.

Indexed as

EugeniaPlant ExtractsUrolithiasisAnimalsCalcium OxalateDose-Response Relationship, DrugFlavanonesMolecular Docking SimulationRatsCalcium OxalateFlavanonespinostrobinPlant Extractscryptostrobineugeniaoxalatephytochemistrypinostrobin

Identifiers

PMID41996621
PMCPMC13090003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.