Evidence map›Paper›PMID 41996578›Full record

ArticleBriefings in bioinformatics2026

Translational bioinformatics stalls at implementation.

Lars Rønn Olsen, Helene Scheel Wegener, Puck Quarles van Ufford, Aimilia Schina, Frederik Kirk, Anne K Winding, Birgitte Hagelskjær, Chelsea Lennox, Chloe Pittman, Christopher T B Strømblad and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Briefings in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Lars Rønn OlsenLEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.ORCID 0000-0002-6725-7850
Helene Scheel WegenerLEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
Puck Quarles van UffordSection for Bioinformatics, Department of Health Technology, Technical University of Denmark, Ørsteds Plads, Building 345B, 2800 Kongens Lyngby, Denmark.
Aimilia SchinaLEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
Frederik KirkDiagnostic Center, Rigshospitalet Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Anne K WindingThe Capital Region of Denmark, Kongens Vænge 2, 3400 Hillerød, Denmark.
Birgitte HagelskjærThe Capital Region of Denmark, Kongens Vænge 2, 3400 Hillerød, Denmark.
Chelsea LennoxCenter for Health Data Science, Section for Health Data Science and Artificial Intelligence, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Søgade 16B, 10.1, 1355 Copenhagen, Denmark.
Chloe PittmanCenter for Health Data Science, Section for Health Data Science and Artificial Intelligence, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Søgade 16B, 10.1, 1355 Copenhagen, Denmark.
Christopher T B StrømbladCenter for Surgical Science, Department of Surgery, Zealand University Hospital, Lykkebækvej 1, 4600 Køge, Denmark.
Ida K BuhlMDxCore, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Inigo P LuengoCenter for Health Data Science, Section for Health Data Science and Artificial Intelligence, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Søgade 16B, 10.1, 1355 Copenhagen, Denmark.
Mads BondeKU Innovation, University of Copenhagen, Nørregade 10, 1165 Copenhagen, Denmark.
Majbritt B MadsenMDxCore, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Mikail GögenurCenter for Surgical Science, Department of Surgery, Zealand University Hospital, Lykkebækvej 1, 4600 Køge, Denmark.
Morten RasmussenDepartment of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg, Denmark.
Nicolas RapinThe Danish National Genome Center, Ørestads Boulevard 5, 2300 Copenhagen, Denmark.
Hermina JakupovicCenter for Health Data Science, Section for Health Data Science and Artificial Intelligence, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Søgade 16B, 10.1, 1355 Copenhagen, Denmark.
Simon RasmussenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.ORCID 0000-0001-6323-9041
Tiara DusselierGraduate School of Life Sciences, Universiteit Utrecht, Heidelberglaan 8, 3584 Utrecht, Netherlands.
Michael KrauthammerDepartment of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.ORCID 0000-0002-4808-1845
Ole LundSection for Bioinformatics, Department of Health Technology, Technical University of Denmark, Ørsteds Plads, Building 345B, 2800 Kongens Lyngby, Denmark.
Signe ModvigDepartment of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Frederik O BaggerMDxCore, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.ORCID 0000-0003-0636-8845

Funding

Greater Copenhagen Health Science PartnersLEO Fondet LF18500Novo Nordisk Fonden NNF23SA0087056Novo Nordisk Foundation Center for Basic Metabolic Research NNF23SA0084103
6 · The paper itself

Abstract

Bioinformatics tools are increasingly important for diagnostics in clinical care and precision medicine, but despite a very active bioinformatics research community, implementation and adaptation is slow. Drawing on multidisciplinary expertise, we have identified key systemic barriers on the journey from research to implementation, using the Danish healthcare ecosystem as the example. We find the main obstacles to be regulatory uncertainty, fragmented data access, and limited infrastructure for implementation. Cultural resistance to commercialization and workforce gaps further impedes progress. We believe that these challenges reflect broader international trends and could be generally applicable. Consensus recommendations include centralized data and regulatory resources, cross-sector collaboration models, and pilot initiatives to support scalable implementation. These findings offer a roadmap for translating bioinformatics innovation into clinical practice.

Indexed as

Computational BiologyTranslational Research, BiomedicalDenmarkHumansbioinformatics researchclinical bioinformaticsimplementationresource managementtranslational bioinformatics

Identifiers

PMID41996578
PMCPMC13089514

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.