ArticleChembiochem : a European journal of chemical biology2026
Ultraviolet Raman Optical Activity as a Window Into Peptide Backbone Structure.
Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The spectroscopy of ultraviolet Raman optical activity (UV ROA) promises an excellent sensitivity to peptide and protein conformation, decoupling the backbone signal from most side chains. Compared to the more usual ROA with visible light, stronger intensity and additional spatial sensitivity are expected because most of the signal comes from the amide chromophore. UV ROA experiments are scarce, and links between spectral shapes and molecular structure are rather unexplored. However, on a dedicated instrument, we could acquire spectra of three peptides and analyze them on the basis of molecular dynamics and density functional theory simulations. Radical differences were observed between the spectra obtained with the 244 and 532 nm excitations, and they could be rationalized by the simulations. Bands connected to the peptide backbone vibrations are enhanced at the shorter wavelength, due to a pre-resonance with the n-π
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