Evidence map›Paper›PMID 41996512›Full record

ArticleScience advances2026

Molecular basis of CXC chemokine receptor 3 ligand multispecificity.

Alexandre Bouyssou, Dawei Sun, Tricia Zhou, Shannon Smith, Hoangdung Ho, Matthew Johnson, Caleigh Azumaya, Sigrid Noreng, Peter Liu, Shu Ti and 6 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alexandre BouyssouDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0009-0004-9294-2229
Dawei SunDepartment of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0009-0005-3379-5369
Tricia ZhouDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0009-0005-1080-3143
Shannon SmithDepartment of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0000-0002-1225-8928
Hoangdung HoDepartment of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0000-0002-1964-0660
Matthew JohnsonDepartment of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0000-0002-1477-7801
Caleigh AzumayaDepartment of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0000-0002-3484-9921
Sigrid NorengDepartment of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0000-0001-5767-1399
Peter LiuDepartment of Proteomic & Genomic Technologies, Genentech Inc., South San Francisco, CA 94080, USA.
Shu TiDepartment of Biomolecular Research, Genentech Inc., South San Francisco, CA 94080, USA.
Prajakta JoshiDepartment of Biomolecular Research, Genentech Inc., South San Francisco, CA 94080, USA.
Christine TamDepartment of Biomolecular Research, Genentech Inc., South San Francisco, CA 94080, USA.
Ying YangDepartment of Computational Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0000-0002-0112-3016
Eric JanezicDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0000-0002-3177-889X
Laëtitia Comps-AgrarDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0000-0002-5260-6536
Matthieu MasureelDepartment of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0000-0002-4059-6166

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

C-X-C motif chemokine receptor 3 (CXCR3) is essential for immune cell functions and pivotal in T helper 1 cell infiltration in autoimmune and chronic inflammatory diseases and in tumor proliferation and metastasis, but the mechanisms by which the endogenous ligands CXCL9, CXCL10, and CXCL11 differentially recognize and activate CXCR3 are not fully understood. Here, we present cryo-electron microscopy structures of all three chemokine-CXCR3-G

Indexed as

Receptors, CXCR3AnimalsBinding SitesChemokine CXCL10Chemokine CXCL11Chemokine CXCL9Cryoelectron MicroscopyHumansLigandsMolecular Dynamics SimulationProtein BindingProtein ConformationSignal TransductionChemokine CXCL10Chemokine CXCL11Chemokine CXCL9CXCL11 protein, humanCXCR3 protein, humanLigandsReceptors, CXCR3

Identifiers

PMID41996512
PMCPMC13089336

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.