Evidence map›Paper›PMID 41996493›Full record

ArticleScience advances2026

Mesoglea biogenesis reveals a cryptic aboral valve for pressure regulation in cnidarian morphogenesis.

Soham Basu, Petrus Steenbergen, Florian Gabler, Alexandre Paix, Paolo Ronchi, Gleb Bourenkov, Thomas R Schneider, Jonas Hellgoth, Anna Kreshuk, Suat Özbek and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Soham BasuDevelopmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0002-6591-6859
Petrus SteenbergenDevelopmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0001-8875-7638
Florian GablerDevelopmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0002-3949-8200
Alexandre PaixDevelopmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0002-8080-7546
Paolo RonchiElectron Microscopy Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0001-9010-533X
Gleb BourenkovEuropean Molecular Biology Laboratory, EMBL Hamburg c/o DESY, Notkestrasse 85, 22603 Hamburg, Germany.ORCID 0000-0002-2617-5920
Thomas R SchneiderEuropean Molecular Biology Laboratory, EMBL Hamburg c/o DESY, Notkestrasse 85, 22603 Hamburg, Germany.ORCID 0000-0001-6955-7374
Jonas HellgothCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0003-0758-1680
Anna KreshukCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0003-1334-6388
Suat ÖzbekCentre for Organismal Studies, Department of Evolutionary Neurobiology, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.
Aissam IkmiDevelopmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0001-6310-8404

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cnidarians are classically defined by a single oral opening, a hallmark of the "blind gut" model in early animal evolution. Here, we identify a pressure-sensitive aboral valve in

Indexed as

CnidariaMorphogenesisSea AnemonesAnimalsBasement MembraneBiomechanical PhenomenaExtracellular MatrixPressure

Identifiers

PMID41996493
PMCPMC13089338

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.