ArticlePloS one2026
Ultra-high dose rate electron FLASH beam irradiation using a modified clinical linear accelerator.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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18 authors.
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Abstract
FLASH radiation therapy reduced radiation-induced damage to normal tissue, compared to conventional radiation therapy, and active studies have been undertaken worldwide. While a number of preclinical studies have revealed the effectiveness of this novel radiotherapy, the biological effects have not been fully elucidated. Here, we implemented ultra-high dose-rate FLASH beam irradiation through machine modifications of the core components of an existing clinical linear accelerator, to build a database containing information related to the biological effects of the FLASH beam. We established a protocol that enables a quick conversion between the CONV and FLASH modes of an existing clinical linear accelerator. At 100 cm source-to-surface distance in 10 cm × 10 cm applicator conditions, we achieved FLASH electron beam irradiation characterized by 9.49 MeV mean energy, effective field size (95% iso-dose distribution) ∅ 39.9 mm, and maximum dose rate of 339.1 Gy/s. Irradiation of an elliptical Gaussian beam with flatness of 12.7% and symmetry of 0.3% was confirmed. Furthermore, most of the required preclinical conditions were satisfied. However, although the pulse dose value obtained from the protocol is expected to meet the requirement of 1 Gy/pulse, this result was not confirmed in this study, and further investigation is required.
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