SynthesisFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
Brain Proteomic Responses to Glucocorticoids and Their Relationship With Transcriptome: A Systematic Meta-Analysis.
Synthesis in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
Abstract
Although there are several proteomic studies testing brain responses to glucocorticoids, there were no attempts to integrate these data and compare them with responses at the level of mRNAs. Furthermore, the utility of available data is compromised by changes in nomenclature and usage of different types of identifiers. Therefore, the aim of this study was to identify the most consistent changes in protein expression in standardized mouse, rat, and human datasets and compare them with transcriptomic responses to glucocorticoids. The analysis showed that the two most frequently and consistently detected proteins were ATP synthase F1 subunit beta (Atp5f1b) and aldolase, fructose-bisphosphate C (Aldoc), while the most consistent proteomic and transcriptomic findings included Aldoc, Plin4, Aqp4, Endod1, Glul, Anln, Aldh1l1, Parp1, Trf, Fermt2, Tmem63a, and Trim2. The study also revealed limitations of available proteomic data indicating significant gaps in knowledge. Finally, the study provides an integrated dataset with updated protein nomenclature and a complete set of major identifiers to facilitate usage of proteomic data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.