Evidence map›Paper›PMID 41996102›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Attenuated pupillary response during visual search in preclinical Alzheimer's disease.

Elena K Festa, William C Heindel, Camille A Marangi, Britney Escobedo, Douglas R Galasko, David P Salmon, Jingjing Zou, Diane M Jacobs

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elena K FestaDepartment of Cognitive and Psychological Sciences, Brown University, Providence, Rhode Island, USA.ORCID 0000-0002-3700-4270
William C HeindelDepartment of Cognitive and Psychological Sciences, Brown University, Providence, Rhode Island, USA.
Camille A MarangiDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Britney EscobedoDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Douglas R GalaskoDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
David P SalmonDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Jingjing ZouUCSD Shiley-Marcos Alzheimer's Disease Research Center, La Jolla, California, USA.
Diane M JacobsDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9M
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
Novel Cognitive Markers of Early Alzheimer's Disease.R01AG064002 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JACOBS, DIANE M. · 2020 to 2024
$2.3M
National Institute on Aging of the National Institutes of Health P30AG062429National Institute on Aging of the National Institutes of Health R01AG064002NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG064002NIA NIH HHS U24 AG021886
6 · The paper itself

Abstract

introductionThe locus coeruleus is among the earliest brain regions affected by tau pathology in Alzheimer's disease (AD), but the functional impact is difficult to measure in vivo. Task-evoked pupil dilation provides an index of locus coeruleus-norepinephrine function that might be altered in cognitively normal older adults with underlying AD pathology.

methodsCognitively normal older adults identified as AD biomarker positive (N = 25) or negative (N = 36) based on plasma phosphorylated tau (p-tau) levels completed a conjunctive visual search task that manipulated attentional load by varying set size. Pupil dilation responses during the task were analyzed using mixed-effects models and time-resolved regression.

resultsDespite comparable accuracy and reaction times, biomarker-positive adults showed reduced load-dependent modulation of pupil dilation during target-present trials. Weaker modulation was associated with higher p-tau levels and poorer executive and memory function. DISCUSSION: Attenuated task-evoked modulation of pupil dilation during visual search reveals locus coeruleus-norepinephrine dysfunction in preclinical AD.

Indexed as

Alzheimer DiseaseAttentionPupilAgedAged, 80 and overBiomarkersFemaleHumansLocus CoeruleusMaleNeuropsychological TestsReaction Timetau ProteinsBiomarkerstau Proteinsattentioncognitive loadlocus coeruleusplasma biomarkerspreclinical Alzheimer's diseasepupillometryvisual search

Identifiers

PMID41996102
PMCPMC13089205

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.