ArticleJournal of bioenergetics and biomembranes2026
The expression of glial cell-derived neurotrophic factor in the hippocampal tissue of rats with vascular dementia and its correlation with molecular pathways involved in learning and memory impairment.
Article in Journal of bioenergetics and biomembranes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
It aimed to investigate the expression of glial cell-derived neurotrophic factor (GDNF) in the hippocampal tissue of rats with vascular dementia (VD) and its correlation with learning and memory functions (LMFs). Additionally, it sought to analyze the impact of factors such as acetylcholine synthesis/metabolism imbalance and oxidative stress on the alteration of GDNF expression and their role in pathogenesis of VD, particularly regarding learning and memory deficits. Wistar rats were randomly rolled into control group (Ctrl, no treatment), sham group (Sham, exposure of bilateral common carotid arteries without occlusion), and VD group (permanent ligation of bilateral common carotid arteries). Morris water maze test assessed the LMFs of rats. Superoxide dismutase (SOD), malondialdehyde (MDA), acetylcholinesterase (AchE), and choline acetyltransferase (ChAT) level changes were monitored. Immunohistochemical staining detected CD34 and GDNF expression levels, while western blot analysis examined vascular endothelial growth factor (VEGF)A and VEGF receptor 2 (VEGFR2) protein expression levels. Rats in VD group had longer escape latencies and greater total swimming distances, along with reduced swimming speeds and fewer platform crossings versus Ctrl and Sham (P < 0.05). VD group had relatively lower hippocampal SOD, AchE, and ChAT activity levels (P < 0.05). VD group had increased CD34 expression level and decreased GDNF expression level versus Ctrl and Sham (P < 0.05). VD group exhibited higher relative expression levels of VEGFA and VEGFR2 proteins in hippocampal tissue than Ctrl and Sham (P < 0.05). VD rats exhibited observable impairments in LMFs, which may be associated with an imbalance in acetylcholine synthesis/metabolism, oxidative stress, and reduced expression level of GDNF in hippocampal tissue.
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