Evidence map›Paper›PMID 41996068›Full record

ReviewCurrent HIV/AIDS reports2026

Expanding PrEP Access Through Decentralized Delivery Models.

Angela Tembo, Tarryn Collings, Tsitsi Nyamuzihwa, Samanta Tresha Lalla Edward, Elzette Rousseau, W D Francois Venter, Linda-Gail Bekker, Danielle Giovenco

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current HIV/AIDS reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Angela TemboFaculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Tarryn CollingsFaculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Tsitsi NyamuzihwaFaculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Samanta Tresha Lalla EdwardFaculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Elzette RousseauDesmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
W D Francois VenterFaculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Linda-Gail BekkerDesmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Danielle GiovencoDesmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa. danielle.giovenco@emory.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review examines emerging PrEP delivery models designed to expand access to HIV prevention outside of traditional clinic settings. It aims to synthesize recent evidence from these models on PrEP uptake, acceptability, and persistence, as well as geographic, social, and structural challenges, drawing on both the research literature and insights from recent programs. RECENT

findingsRecent studies have highlighted the potential of decentralized PrEP delivery approaches, including community-based distribution, pharmacy-based PrEP provision, telePrEP, and automated PrEP dispensing. These models can improve access, reduce stigma, and provide more personalized care. Hybrid approaches and integration of digital tools and peer support have also shown promise in enhancing adherence and retention. However, challenges related to effectiveness, scalability, regulatory constraints, and cost-effectiveness remain. Decentralized PrEP delivery models offer flexible, client-centered solutions that can significantly expand access to HIV prevention for vulnerable groups. Future research should focus on implementation and policy innovation to support integratration of these models into existing health systems and reach underserved populations.

Indexed as

Anti-HIV AgentsHealth Services AccessibilityHIV InfectionsPre-Exposure ProphylaxisHumansAnti-HIV AgentsCommunity PrEPDifferentiated Service DeliveryHIV PreventionPrEPTelePrEP

Identifiers

PMID41996068

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.