Evidence map›Paper›PMID 41996034›Full record

ArticleClinical and experimental nephrology2026

Seasonal variation of salt intake in patients with chronic kidney disease correlates with that of systolic blood pressure in males in summer.

Naro Ohashi, Yuri Uchiyama, Yoshimichi Yamashiro, Sayaka Ishigaki, Shinsuke Isobe, Chiemi Ema, Takamitsu Sasaki, Masanori Sakakima, Naoki Ikegaya, Takamasa Iwakura and 4 more

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Article in Clinical and experimental nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

14 authors.

Naro OhashiPostgraduate Clinical Education Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-Ku, Hamamatsu, 431-3192, Japan. ohashi-n@hama-med.ac.jp.ORCID http://orcid.org/0000-0001-7023-1638
Yuri UchiyamaInternal Medicine 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-Ku, Hamamatsu, 431-3192, Japan.
Yoshimichi YamashiroInternal Medicine 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-Ku, Hamamatsu, 431-3192, Japan.
Sayaka IshigakiBlood Purification Unit, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-Ku, Hamamatsu, 431-3192, Japan.
Shinsuke IsobeBlood Purification Unit, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-Ku, Hamamatsu, 431-3192, Japan.
Chiemi EmaInternal Medicine 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-Ku, Hamamatsu, 431-3192, Japan.
Takamitsu SasakiDepartment of Nephrology, Fujieda Municipal General Hospital, 4-1-11 Surugadai, Fujieda, 426-8677, Japan.
Masanori SakakimaDepartment of Nephrology, Fujinomiya City General Hospital, 3-1 Nishikimachi, Fujinomiya, 418-0076, Japan.
Naoki IkegayaDepartment of General Medicine, Yaizu City Hospital, 1000 Michihara, Yaizu, 425-8505, Japan.
Takamasa IwakuraInternal Medicine 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-Ku, Hamamatsu, 431-3192, Japan.
Tomoyuki FujikuraInternal Medicine 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-Ku, Hamamatsu, 431-3192, Japan.
Akihiko KatoBlood Purification Unit, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-Ku, Hamamatsu, 431-3192, Japan.
Akira HishidaDepartment of Nephrology, Japanese Red Cross Hamamatsu Hospital, 1088-1, Kobayashi, Hamana-Ku , Hamamatsu, 434-8533, Japan.
Hideo YasudaInternal Medicine 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-Ku, Hamamatsu, 431-3192, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBlood pressure (BP) displays a higher seasonal variation in winter than in summer. However, evidence of seasonal variations in salt intake is limited. No study has evaluated the same individuals over time using daily urine collection. Further, there are no reports that demonstrates the relationship between BP and salt intake by sex on a seasonal basis.

methodsThis study included 168 patients with chronic kidney disease (CKD) (mean 62.1 years, 93 males) over a 1-year period. We analyzed the seasonal variation between summer and winter in 147 patients with CKD for whom both summer and winter data were available. In addition, we evaluated 90 patients separately who were not taking medications that impact urinary sodium excretion.

resultsIn 147 patients, body weight, body mass index (BMI), BP, choline esterase (ChE), low-density lipoprotein (LDL) cholesterol, and salt intake were higher in winter in males, whereas only BP, albumin, ChE and LDL cholesterol were higher in winter in females. In the multiple regression analyses, systolic BP significantly and positively correlated with salt intake in males and this trend was more pronounced in summer. Contrarily, females did not show a correlation between systolic BP and salt intake in both summer and winter. Moreover, the 90 patients who were not taking medications that impact sodium excretion showed a similar relationship between systolic BP and salt intake.

conclusionSalt intake in patients with CKD was higher in winter. Furthermore, the correlation between systolic BP and salt intake was particularly pronounced in males in summer.

Indexed as

Blood PressureRenal Insufficiency, ChronicSeasonsSodium Chloride, DietaryAgedFemaleHumansHypertensionMaleMiddle AgedSex FactorsSodium Chloride, DietaryBlood pressureDaily urinary collectionSalt intakeSeasonal variationSex

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.