Evidence map›Paper›PMID 41996029›Full record

ArticleMolecular neurobiology2026

Less Is More: A Physiological Dose of Vitamin B12 Enhances Neural Recovery Compared to a High Dose in an H₂O₂-Stressed SH-SY5Y Neural-Like Cell Model.

Aimee Rachel Mathew, Luca Buccini, Anacleto Proietti, Giacomo Di Matteo, Erisa Selita, Ilaria Serangeli, Roberta Stefanelli, Elisa Gazzera, Francesco Mura, Luisa Mannina and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Aimee Rachel MathewDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-6546-9377
Luca BucciniDepartment of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-5862-2484
Anacleto ProiettiDepartment of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-9421-4354
Giacomo Di MatteoDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-0110-5010
Erisa SelitaDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0009-0005-1579-6229
Ilaria SerangeliFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0001-9460-6844
Roberta StefanelliDepartment of Psychology, Division of Neuroscience, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-7782-7757
Elisa GazzeraDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.
Francesco MuraDepartment of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-8490-9438
Luisa ManninaDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-8659-5890
Marco RossiDepartment of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-7603-1805
Antonella De JacoDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-9394-0207
Elena MirandaDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-0586-8795
Ada Maria TataDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0003-4868-5435
Livia AngeloniDepartment of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-0490-9225
Piergiorgio La RosaDepartment of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, Rome, Italy.ORCID http://orcid.org/0000-0002-9723-2363
Daniele PasseriDepartment of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-8189-1359
Virve Cavallucci *Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0003-3082-6359
Marco Fidaleo *Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy. marco.fidaleo@uniroma1.it.ORCID http://orcid.org/0000-0002-1287-9601

Funding

Sapienza Università di Roma AR123188A13167D9 and AR224190736FCDC1Sapienza Università di Roma RM12117A86B6FF27Sapienza Università di Roma RP12117A5C8B6DC1, P1221816749A2A8 and RM124190EE61B8D3
6 · The paper itself

Abstract

Vitamin B12 (VitB12) plays a crucial role in neural homeostasis, and a high dose is preferred as treatment to support recovery from neural impairments. However, a significant knowledge gap remains regarding its dose-dependent effects, particularly in its influence on cellular recovery following neural damage. To address this, we utilized retinoic acid-differentiated SH-SY5Y cells, as an in vitro neural model, where we induced neural damage using hydrogen peroxide (H

Indexed as

Hydrogen PeroxideModels, BiologicalNeuronsOxidative StressVitamin B 12AntioxidantsCell Line, TumorCell SurvivalDose-Response Relationship, DrugHumansMitochondriaNeuritesAntioxidantsHydrogen PeroxideVitamin B 12Lipid remodelingMitochondrial activityNeural recoveryNeurite outgrowthOxidative damageSH-SY5Y modelVitamin B12

Identifiers

PMID41996029
PMCPMC13090186

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.