ArticleAIDS and behavior2026
Alignment Between HIV Vulnerability and Pre-exposure Prophylaxis Use in a Longitudinal Study of Young, Black Men Who Have Sex with Men.
Article in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
7 authors.
Funding
Abstract
When taken as a daily pill, pre-exposure prophylaxis (PrEP) requires sufficient levels of adherence to confer strong protection against HIV. For protection against HIV transmission via anal sex, this corresponds to at least 4 daily pills per week for those on a daily dosing regimen. Measuring oral PrEP adherence requires valid assessments of pill-taking; it also requires assessments of contemporaneous sexual behavior because PrEP adherence is only functionally relevant in the context of contemporaneous HIV vulnerability. We conducted an online cohort study of Black, PrEP-using men who have sex with men (MSM) to assess the alignment between self-reported PrEP adherence and condom use and concordance between self-reported PrEP adherence and laboratory-assessed adherence. Data collection occurred from 2021 to 2023. Participants completed 11 weekly surveys to report PrEP use and sexual behavior for the preceding 7 days. At the end of follow-up, they were asked to submit a dried blood spot sample for laboratory analysis. There were few periods of self-reported non-adherence, but, among these, condomless sex was frequent. Self-reported adherence was not predictive of laboratory-assessed adherence. Despite their cost, studies of PrEP adherence should incorporate laboratory measurements of adherence whenever feasible.
Identifiers
41995920What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.