ReviewCurrent atherosclerosis reports2026
From Storage to Signaling: Lipid Droplet Lipolysis in Cholesterol Mobilization and Foam Cell Remodeling.
Review in Current atherosclerosis reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
purpose of reviewSterol ester mobilization from foam cell lipid droplets (LDs) involves lipase-mediated hydrolysis. This review summarizes the main lipolytic pathways, with emphasis on their potential impact on foam cell modulation through induction of liver X receptor (LXR) signaling. RECENT
findingsRecent work links foam cells to alternatively activated, low-inflammatory phenotypes and identify LXR activation as a potential driver of this state. Neutral cholesterol ester hydrolases (NCEHs) that associate with LDs have been shown to induce LXR target genes. Beyond their central roles in lipid storage, LDs act as metabolic hubs of bioactive lipids. Enzymes that liberate sterols from LD depots can both initiate reverse cholesterol transport and promote sterol signaling. Although lipolytic signaling remains an underexplored aspect of foam cell biology, current evidence suggests that the cellular compartment where free sterols are released may influence their activity, and cytosolic NCEHs associated with LDs could play a more direct role in modulating LXR activation.
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Registered trials
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