Evidence map›Paper›PMID 41995880›Full record

ArticleActa neuropathologica2026

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.

Andrew Fang, Xinli Tang, Madeleine Fleming, Brian Tancowny, Xiongyao Wang, YongLiang Wang, Nathalie Daude, Lyudmyla Dorosh, Shelaine C Fleck, Vineet Rathod and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Andrew FangDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.
Xinli TangDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.
Madeleine FlemingDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.
Brian TancownyDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.
Xiongyao WangDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.
YongLiang WangDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.
Nathalie DaudeCentre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.
Lyudmyla DoroshDepartment of Electrical & Computer Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.
Shelaine C FleckDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.
Vineet RathodDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.
Virginie CoustouInstitut de Biochimie et de Génétique Cellulaire, Centre National de La Recherche Scientifique, IBGC, UMR 5095, 33077, Bordeaux, France.
Silvia A CervantesZilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, 90033, USA.
Camilo Duque VelásquezCentre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.
David WestawayCentre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.
Judd AikenCentre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.
Debbie McKenzieCentre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.
Glenn TellingDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, 80523, USA.
Maria StepanovaDepartment of Electrical & Computer Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.
Sven J SaupeInstitut de Biochimie et de Génétique Cellulaire, Centre National de La Recherche Scientifique, IBGC, UMR 5095, 33077, Bordeaux, France.
Ansgar B SiemerZilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, 90033, USA.
Holger WilleDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada. wille@ualberta.ca.

Funding

Zoonotic potential of CWD and influence of environmental contamination on prion propagationP01AI077774 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CLAUDIO SOTO · 2008 to 2026
$36.1M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Structural characterization of A-beta strain variation in AD mouse modelsR01AG061865 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LANGEN, RALF, SIEMER, ANSGAR B · 2018 to 2022
$4.2M
Chronic Wasting Disease VaccinesR01AI156037 · NIAID · COLORADO STATE UNIVERSITY · PI MATHIASON, CANDACE K. · 2021 to 2025
$3.5M
Maximizing research success in studies of naturally-occurring prion diseasesR35NS132226 · NINDS · COLORADO STATE UNIVERSITY · PI Glenn C Telling · 2023 to 2026
$3.1M
Intrinsically disordered domains of α-synuclein: effect of fibril formation and fibril polymorphsR01NS133820 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Ansgar B Siemer · 2024 to 2026
$2.0M
Alberta Conservation Association 030-00-90-320Alberta Environment and Protected Areas 24GRLND130Alberta Innovates 212200469Alberta Ministry of Technology and Innovation SPP-ARC (Striving for Pandemic Preparedness - The Alberta Research Consortium)Alberta Prion Research Institute 201600023Alberta Prion Research Institute 20160012Canada Foundation for Innovation 39588Creutzfeldt-Jakob Disease Foundation Katie Dopirak Memorial GrantNatural Sciences and Engineering Research Council of Canada ALLRP 571218-21NIAID NIH HHS P01 AI077774NIA NIH HHS R01 AG061865NIGMS NIH HHS R01 GM129325NIH HHS P01AI077774NIH HHS R01 AI156037NIH HHS R01 NS133820NINDS NIH HHS R35 NS132226Results Driven Agriculture Research 2025T3838R
6 · The paper itself

Abstract

Prion diseases are transmissible, fatal, neurodegenerative disorders driven by the conformational misfolding of the cellular prion protein (PrP

Indexed as

Gerstmann-Straussler-Scheinker DiseaseVaccinesAnimalsDisease Models, AnimalMiceMice, TransgenicMutationPrPSc ProteinsPrPSc ProteinsVaccinesEpitope predictionGSSMolecular modelingPrion vaccineProtein engineeringStructure-based vaccine

Identifiers

PMID41995880
PMCPMC13090231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.