Evidence map›Paper›PMID 41995855›Full record

ArticlePlant cell reports2026

AtGASA1 positively regulates Arabidopsis response to salt stress by suppressing accumulation of reactive oxygen species.

Jian-Bo Song, Hao-En He, Cai-Feng Wang, Xian-Zhi Zuo, Zi-Xin Zhao, Ya-Ru Li, Yu-Fan Chen, Shu-Fan Liu, Han-Wen Guo, Xuan Huang

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Article in Plant cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Jian-Bo Song *Provincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Xi'an, China.
Hao-En He *Provincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Xi'an, China.
Cai-Feng WangProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Xi'an, China.
Xian-Zhi ZuoProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Xi'an, China.
Zi-Xin ZhaoProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Xi'an, China.
Ya-Ru LiProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Xi'an, China.
Yu-Fan ChenProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Xi'an, China.
Shu-Fan LiuProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Xi'an, China.
Han-Wen GuoProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Xi'an, China.
Xuan HuangProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Xi'an, China. xuanhuang@nwu.edu.cn.ORCID http://orcid.org/0000-0001-9670-0930

Funding

International Science and Technology Cooperation Project 2024GH-YBXM-23National Natural Science Foundation of China 31300223National Training Programs of Innovation and Entrepreneurship for Undergraduate 202210697001Natural Science Foundation of Shaanxi Province 2016JM3001Natural Science Foundation of Shaanxi Province 2025JC-YBMS-241
6 · The paper itself

Abstract

key messageAtGASA1 regulates plant growth and development, while conserved Cys-40 and Cys-44 residues in its GASA domain are crucial for controlling ROS accumulation under salt stress. AtGASA1 is a member of the gibberellin acid-stimulating protein (GASA) family, characterized by a GASA domain containing 12 conserved cysteine-rich peptides (CRP). Members of the GASA family are known to play an essential role in plant responses to both biotic and abiotic stresses; however, the function of AtGASA1 remains unclear. In this study, we found that gasa1 mutants exhibited sensitivity to salt stress, accompanied by increased accumulation of reactive oxygen species (ROS). In contrast, AtGASA1-overexpressing plants exhibited enhanced salt tolerance and significantly reduced ROS levels. These findings indicate that AtGASA1 positively regulates salt stress tolerance, likely through modulating ROS homeostasis. To explore the role of conserved cysteine residues within the GASA domain, site-directed mutagenesis was performed to substitute Cys-40 and Cys-44 with alanine. Functional assays in a yeast heterologous expression system showed that yeast expressing AtGASA1

Indexed as

ArabidopsisArabidopsis ProteinsReactive Oxygen SpeciesSalt StressAmino Acid SequenceGene Expression Regulation, PlantGibberellinsMutationPlants, Genetically ModifiedSalt ToleranceSodium ChlorideArabidopsis ProteinsGASA protein, ArabidopsisGibberellinsReactive Oxygen SpeciesSodium ChlorideArabidopsisAtGASA1GAReactive oxygen species (ROS)Salt stress

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.