Leaflet Length is a Reliable Measure of Aortic Valve Growth.

Timothy E Nissen, Simon Chung, Andrew W Brown, Emily Sanders, Nirbhay Parashar, Almontasser Bella Kassier, Kenneth R Knecht, Taufiek Konrad Rajab, Amna Qasim

Abstract read

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Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

9 authors.

Timothy E NissenDivision of Pediatric Cardiology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA. TENissen@uams.edu.ORCID http://orcid.org/0000-0002-7412-7130

Simon ChungDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID http://orcid.org/0000-0003-2349-3779

Andrew W BrownDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID http://orcid.org/0000-0002-1758-8205

Emily SandersDivision of Pediatric Cardiology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA.ORCID http://orcid.org/0009-0009-0648-9904

Nirbhay ParasharDivision of Pediatric Cardiology, Department of Pediatrics, LeBonheur Children's Hospital, Memphis, TN, USA.ORCID http://orcid.org/0009-0005-1807-5785

Almontasser Bella KassierDepartment of Cardiovascular Pediatric Surgery, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID http://orcid.org/0000-0003-0473-2930

Kenneth R KnechtDivision of Pediatric Cardiology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA.ORCID http://orcid.org/0000-0002-4228-4473

Taufiek Konrad Rajab *Department of Cardiovascular Pediatric Surgery, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID http://orcid.org/0000-0001-8885-2758

Amna Qasim *Division of Pediatric Cardiology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA.ORCID http://orcid.org/0000-0002-0592-6705

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of partial heart transplant (PHT) of living valves necessitates robust measures of valve growth. Traditional measurement of aortic valve annular dimension can be confounded by cardiac dilation and does not evaluate the growth of aortic valve leaflets. Measurement of valve leaflet length growth over time has not been studied. We conducted a retrospective cohort study of 12 infants post–orthotopic heart transplant (OHT) and 12 infants with ventricular septal defects (VSDs) with ≥ 5 years of serial echocardiographic data. Leaflet length and annular dimension were measured, and inter-rater reliability assessed. Aortic leaflet length demonstrated good inter-rater reliability and consistent growth over time. Leaflet length is a reliable, feasible, and theoretically dilation-independent measure of semilunar valve growth and may improve longitudinal assessment in patients undergoing PHT.

Indexed as

Aortic valveEchocardiographyLeaflet lengthPartial heart transplantPulmonary valve

Identifiers

PMID41995821

DOI10.1016/j.athoracsur.2023.03.023

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