ReviewMolecular biology reports2026
Crossroads of iron, copper, and zinc in cancer: a paradox of toxicity and therapy.
Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Heteronemin suppresses chemoresistant oral squamous cell carcinoma cells through ROS-mediated apoptosis and cuproptosis-associated mitochondrial stress.Apoptosis : an international journal on programmed cell death · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Groups 8, 11, and 12 of the periodic table contain several biologically relevant trace elements, among which iron, copper, and zinc play critical roles in numerous cellular processes, including oxygen homeostasis, enzymatic activity, mitochondrial metabolism, reactive oxygen species (ROS) regulation, DNA synthesis, and gene expression. These elements are essential for maintaining cellular physiology; however, disturbances in their homeostasis can trigger a cascade of molecular events within the tissue microenvironment.This review highlights the interconnected regulatory pathways of iron, copper, and zinc and discusses their dual roles in cancer biology, functioning both as promoters of tumour progression and as mediators of tumour suppression. We further examine the mechanisms through which metal dysregulation contributes to cellular toxicity, oxidative stress, and metabolic reprogramming in cancer. In addition, emerging therapeutic strategies targeting metal homeostasis are discussed, including approaches aimed at modulating metal overload, deficiency, and metal-dependent signalling pathways.By integrating current knowledge on the biological roles and pathological consequences of trace metal imbalance, this review provides a comprehensive perspective on how metal dyshomeostasis contributes to cancer development and highlights the potential of metal-targeted therapeutic strategies in cancer management.
Indexed as
Identifiers
41995783What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.