ReviewSchmerz (Berlin, Germany)2026
[Migraine in men: biological, psychosocial and clinical characteristics].
Review in Schmerz (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMigraine affects 15% of the global population, with men being 2-3 times less frequently affected than women and are markedly underrepresented in research and clinical care. The condition is frequently underdiagnosed in men.
objectiveThe aim of this work is to describe the biological and psychosocial characteristics of migraine in men in order to improve the understanding of sex-related differences and to enhance the diagnostic precision and treatment for men. MATERIAL AND
methodsThis article is a narrative review based on a structured literature search in PubMed using relevant search terms related to migraine and sex differences.
resultsBiologically, men differ from women through hormonal influences on the calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP) and transient receptor potential (TRP) signaling pathways, which modulate pain processing. Clinically, men exhibit on average shorter attacks, lower intensity, more frequently dull-pressing pain and fewer vegetative accompanying symptoms. This presentation often leads to misdiagnosis. Additionally, role expectations, stigma and lower help-seeking behavior contribute to symptoms being reported later and underestimated more often. Although modern therapies are similarly effective in both sexes, men receive prophylactic treatment less frequently.
conclusionThe sex-specific biological and psychosocial differences demonstrate that men present with a distinct clinical phenotype of migraine. Greater awareness with respect to these characteristics could enhance the diagnostic accuracy and support more individualized treatment.
Indexed as
Identifiers
41995752What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.