Evidence map›Paper›PMID 41995740›Full record

ArticleEuropean radiology2026

Features of low-dose CT-detected lung nodules: individuals who never smoked vs. who smoke(d) in a Chinese general population.

Yifei Mao, Monique D Dorrius, Grigory Sidorenkov, Marcel van Tuinen, Xiaofei Yang, Xiaonan Cui, Zhaoxiang Ye, Rozemarijn Vliegenthart, Geertruida H de Bock, Marjolein A Heuvelmans

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yifei MaoDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Monique D DorriusRadiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Grigory SidorenkovDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Marcel van TuinenRadiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Xiaofei YangDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Xiaonan CuiDepartment of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Centre for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Zhaoxiang YeDepartment of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Centre for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Rozemarijn VliegenthartRadiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Geertruida H de BockDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Marjolein A HeuvelmansDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.a.heuvelmans@umcg.nl.ORCID http://orcid.org/0000-0002-5712-4085

Funding

China Scholarship Council CSC no. 202008440409National Science and Technology Major Project 2024ZD0520000National Science and Technology Major Project 2024ZD0520002Royal Netherlands Academy of Arts and Sciences PSA_SA_BD_01
6 · The paper itself

Abstract

objectivesTo evaluate and compare low-dose CT (LDCT)-defined pulmonary nodule features between individuals who never smoked and who smoke(d) in a Chinese general population. MATERIALS AND

methodsThis study included 2033 participants from the Nelcin-B3 cohort who underwent baseline LDCT. Trained radiologists reviewed each CT scan and assessed nodule CT features, including nodule density, size, location, shape, edge, attachment type, calcification and perifissural nodules (PFNs). Multilevel logistic regression (adjusted for age and sex) was performed to evaluate the relationship between nodule CT features and smoking status, accounting for nodule clustering within participants.

resultsOverall, 36.7% (746/2033) of participants had at least one ≥ 30.0 mm

conclusionIn the Chinese general population, smoking status was associated with lung nodule prevalence and nodule number, but not with key nodule CT features. These findings suggest that in Asian populations, nodule characteristics may be influenced by factors beyond smoking, underscoring the need for population-specific risk stratification strategies in lung nodule assessment. KEY POINTS: Question Lung nodule risk stratification relies on their CT features, yet no Asian studies have comprehensively examined these features between individuals who never smoked and who smoke(d). Findings CT features of lung nodules (e.g., size, location, morphology) showed no significant differences between smoking groups in a Chinese general population, despite observed differences in nodule prevalence and count. Clinical relevance Relying solely on smoking history may underestimate the malignancy risk of lung nodules in Asian populations, emphasizing the need for population-specific risk stratification strategies.

Indexed as

Lung NeoplasmsSmokingSolitary Pulmonary NoduleTomography, X-Ray ComputedAgedChinaEast Asian PeopleFemaleHumansMaleMiddle AgedRadiation DosageLung neoplasms/diagnostic imagingMultiple pulmonary nodules/diagnostic imagingTobacco smoking/adverse effectsTomographyX-ray computed

Identifiers

PMID41995740
PMCPMC13341849

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