Evidence map›Paper›PMID 41995739›Full record

Trial reportEuropean radiology2026

Radiological classification of non-anastomotic biliary strictures after liver transplantation.

Chikako Endo, Jules J G Slangen, Rianne van Rijn, Iris E M de Jong, Hans Blokzijl, Joris Blondeel, Miriam Cortes Cerisuelo, Minneke J Coenraad, Sarwa Darwish Murad, Michail Doukas and 9 more

Registry-linked trialAbstract readClinical Trial, Phase IIIMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02584283 (A Multicenter Randomized Controlled Trial to Compare the Efficacy of End-ischemic Dual Hypothermic Oxygenated Perfusion With Standard Static Cold Storage of Liver Grafts Donated After Circulatory Death in Preventing Biliary Complications), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02584283 phase3completednot on this map

A Multicenter Randomized Controlled Trial to Compare the Efficacy of End-ischemic Dual Hypothermic Oxygenated Perfusion With Standard Static Cold Storage of Liver Grafts Donated After Circulatory Death in Preventing Biliary Complications

TypeinterventionalSponsorRobert J. PorteRan2016 to 2020Enrolled157ConditionsLiver Failure, End Stage Liver Disease, Biliary Tract DiseasesArmsDual hypothermic oxygenated perfusion, Liver Assist®, Perfusion fluid, Glutathione
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Chikako EndoDepartment of Surgery, Section Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jules J G SlangenDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Rianne van RijnDepartment of Surgery, Section Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Iris E M de JongErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hans BlokzijlDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Joris BlondeelTransplantation Research Group, Department of Microbiology, Immunology, and Transplantation, KU Leuven and Department of Abdominal Transplantation Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium.
Miriam Cortes CerisueloInstitute of Liver Studies, Kings College Hospital NHS Foundation Trust, London, United Kingdom.
Minneke J CoenraadDepartment of Gastroenterology and Hepatology, Transplant Center, Leiden University Medical Center, Leiden, The Netherlands.
Sarwa Darwish MuradDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Michail DoukasDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hasan EkerDepartment of Transplant Surgery, Ghent University Hospital, Ghent, Belgium.
Volkert A L HuurmanDepartment of Surgery, Transplant Center, Leiden University Medical Center, Leiden, The Netherlands.
Vincent E de MeijerDepartment of Surgery, Section Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Diethard MonbaliuTransplantation Research Group, Department of Microbiology, Immunology, and Transplantation, KU Leuven and Department of Abdominal Transplantation Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium.
Ivo J SchurinkErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Wojciech G PolakErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jeroen de JongeErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Robert J PorteDepartment of Surgery, Section Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Robbert J de HaasDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. r.j.de.haas@umcg.nl.ORCID http://orcid.org/0000-0002-4915-6781

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDue to donor liver shortage, donation after circulatory death (DCD) livers are increasingly used for liver transplantation (LT). However, non-anastomotic biliary strictures (NAS) are more often observed after DCD LT, which can cause serious morbidity. To provide early adequate NAS-treatment, reliable NAS classification is pivotal. Therefore, the current study determined the clinical applicability of two radiological NAS-classification systems, namely the system of Croome and the Groningen system. MATERIALS AND

methodsPatients included in the dual hypothermic oxygenated perfusion (DHOPE)-DCD trial (NCT02584283) who underwent LT between January 2016 and July 2019, and in whom per-protocol biliary imaging studies 6 months post-LT were available, were included in the study. NAS severity according to both scoring systems was scored by two independent radiologists, and the correlation for each system with clinical outcomes was made.

resultsIn total, 133 patients were included. In our study population, both systems showed good correlation with clinical outcomes, as the highest rates of NAS-related cholangitis and biliary interventions were observed in patients with diffuse necrosis or multifocal progressive disease according to the Croome classification, and likewise in the moderate and severe NAS subgroups in the Groningen classification. Worst 5-year graft and patient survival rates were observed in the case of diffuse necrosis (77% and 80%) or severe NAS (81% and 67%).

conclusionBoth the radiological NAS classification system of Croome and the Groningen NAS classification system correlate well with clinical outcomes. As the Groningen NAS classification system does not necessitate follow-up imaging, it may be the preferred radiological NAS classification system. KEY POINTS: Question Given the potential severity of non-anastomotic biliary strictures after liver transplantation, there is a critical need for adequate radiological classification systems with strong clinical correlations. Findings Both radiological non-anastomotic biliary strictures classification systems of Croome et al and the Groningen system correlated well with clinical outcomes, but no follow-up imaging is needed in the Groningen system. Clinical relevance The Groningen non-anastomotic biliary strictures classification system is easy-to-use, serves as treatment guidance, and provides important prognostic information.

Indexed as

CholestasisLiver TransplantationPostoperative ComplicationsAdultConstriction, PathologicFemaleHumansMaleMiddle AgedBiliary tract diseasesLiver transplantMagnetic resonance imaging

Identifiers

PMID41995739
PMCPMC13342394

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.