ArticleJournal of proteome research2026
Top-Down Proteomics of Zebrafish Brain Regions Using Capillary Zone Electrophoresis-Tandem Mass Spectrometry.
Article in Journal of proteome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Understanding region-specific proteoform profiles in the brain is crucial for deciphering neural function and identifying therapeutic targets. Zebrafish (Danio rerio) is a valuable vertebrate model for neuroscience research due to its substantial conservation of brain structure and function with that of mammals. We present a label-free quantitative top-down proteomics (TDP) analysis of distinct zebrafish brain regions using microdissection and capillary zone electrophoresis-tandem mass spectrometry (CZE-MS/MS). We analyzed four anatomically distinct regions─telencephalon (Tele), combined habenula-optic tectum (Tec/Hab), cerebellum (Cer), and medulla (Med)─identifying 1,050 proteoforms from 336 proteins. Only 89 proteoforms (5.1%) were shared across all regions, demonstrating substantial proteoform heterogeneity. Quantitative comparisons of proteoform intensity between any two brain regions revealed drastic proteoform abundance differences. Interestingly, proteoforms of the same genes (i.e.,
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