Evidence map›Paper›PMID 41995548›Full record

ReviewMedicine2026

Mechanism of microcirculation disturbance in diabetic nephropathy: A review.

Weikang Tang, Huixia Liu, Xuan Li, Siyao Deng, Changyu Gao

Abstract readReview
In one paragraph

Review in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weikang TangSchool of Medicine, Tarim University, Alaer, Xinjiang, China.ORCID 0009-0001-7721-7625
Huixia LiuSchool of Medicine, Tarim University, Alaer, Xinjiang, China.
Xuan LiSchool of Medicine, Tarim University, Alaer, Xinjiang, China.
Siyao DengSchool of Medicine, Tarim University, Alaer, Xinjiang, China.ORCID 0000-0002-1513-2730
Changyu GaoDepartment of Prescription Science, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy, as one of the most serious microvascular complications of diabetes, has an extremely complex pathogenesis. Currently, there are still no effective treatment methods available in clinical practice that can effectively prevent its pathological progression. In recent years, it has been discovered that the microcirculation system facilitates the exchange of substances between blood and tissues, profoundly influencing the homeostasis of the internal environment within the body. Abnormalities in renal microcirculation are closely related to the occurrence and development of diabetic nephropathy. Given the significant importance of improving renal microcirculation disorders in delaying the progression of diabetic nephropathy, by exploring the pathological association between microcirculation disorders and diabetic nephropathy, this paper elaborates on the "key node" role of microvascular lesions in the course of diabetic nephropathy, and conducts an analysis of the signaling pathways. It explains the interactions among cellular signal transduction, growth transformation factors, and oxidative stress pathways in microvascular lesions, providing a more comprehensive theoretical basis and research direction for the treatment strategy of diabetic nephropathy targeting improving renal microcirculation disorders.

Indexed as

Diabetic NephropathiesKidneyMicrocirculationAnimalsDisease ProgressionHumansOxidative StressRenal CirculationSignal Transductiondiabetic nephropathymicrocirculationpathogenesissignaling pathways

Identifiers

PMID41995548
PMCPMC13095291

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.