SynthesisMedicine2026
Effectiveness of cognitive behavioral therapy for depression in patients with multiple sclerosis: A systematic review and meta-analysis.
Synthesis in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe efficacy and methodologies of cognitive behavioral therapy (CBT) for treating depression in multiple sclerosis (MS) require further comprehensive research.
methodsTwo researchers conducted independent literature searches across 5 databases, utilizing the keywords "multiple sclerosis," "cognitive behavioral therapy," and "depression," without any restrictions on publication year. The Cochrane Risk of Bias Tool 2.0 was utilized to assess the included studies. Statistical analyses were conducted using standardized mean difference as the effect size with Stata 17.0 software.
resultsThis meta-analysis included 22 studies. The results indicate that, regardless of whether delivered face-to-face, online, or via telephone, both individual and group CBT effectively alleviate depression in patients with MS. Significant improvements in depressive symptoms were observed starting from the second month of intervention and persisted for up to 6 months post-intervention.
conclusionPatients with MS can flexibly choose the delivery modality of CBT based on their individual circumstances while engaging in treatment for around 2 months. They are encouraged to reengage in CBT within 6 months post-intervention to ensure the continuity and stability of depression treatment outcomes. Healthcare providers can offer various CBT delivery modalities based on the individual preferences and circumstances of patients with MS, while developing corresponding plans to enhance the effectiveness of depression management.
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