ArticleRadiology. Imaging cancer2026
Radiomics-based Differentiation of Recurrent Brain Metastases from Treatment Effects: A Multi-Institutional Comparative Study with Advanced Imaging.
Article in Radiology. Imaging cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose To compare the ability of radiomics, advanced imaging modalities, and Response Assessment in Neuro-Oncology Brain Metastases (RANO-BM) criteria to distinguish tumor recurrence from treatment effects in patients with brain metastasis. Materials and Methods Posttreatment MRI (gadolinium-enhanced T1-weighted, T2-weighted, fluid-attenuated inversion recovery [FLAIR]) data of patients from three institutions, obtained between January 2001 and March 2023, were retrospectively analyzed. Reference standards were established by histopathology or according to clinical and imaging courses. Following preprocessing and segmenting tumors into subcompartments of enhancing lesion, edema, or necrotic core, 1104 radiomic features were extracted, and classification was conducted using random forest models. A comparative assessment with advanced imaging and RANO-BM was performed using a subset of studies with available modalities (dynamic susceptibility contrast MRI, fluorine 18 [
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