Evidence map›Paper›PMID 41995458›Full record

ArticleJournal of Parkinson's disease2026

Autoradiography and preclinical PET studies with radiolabeled asyn-44 and ACI-12589 for imaging α-synuclein.

Cassis Varlow, Anna Pees, Jeffrey S Stehouwer, Ann-Kathrin Grotegerd, Daniel Bleher, Dinahlee Saturnino Guarino, Anton Lindberg, Junchao Tong, Brian J Lopresti, Ashley C Knight and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Cassis VarlowNeurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0003-1217-764X
Anna PeesAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID 0000-0001-8207-3358
Jeffrey S StehouwerDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Ann-Kathrin GrotegerdWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany.
Daniel BleherWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany.ORCID 0000-0002-2216-2524
Dinahlee Saturnino GuarinoDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Anton LindbergAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Junchao TongAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Brian J LoprestiDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Ashley C KnightPreclinical and Translational Sciences - Imaging, Takeda Pharmaceutical Company, Cambridge, MA, USA.
Merlin ZabrockiDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Arafat NasserNeurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Vladimir ShalgunovDepartment of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-8956-1207
Elena FerriHealth Innovative Products and Technologies (HIP-TECH) PhD Program, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0009-0000-0360-8538
Giuseppe CannazzaDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Paul McQuadePreclinical and Translational Sciences - Imaging, Takeda Pharmaceutical Company, Cambridge, MA, USA.
Chester A MathisDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-9811-0950
Robert H MachDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Umberto M BattistiDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kristina HerfertWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany.
Matthias M HerthDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Gitte M KnudsenNeurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Neil VasdevAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.

Funding

Medicinal Chemistry CoreU19NS110456 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ROBERT H MACH · 2019 to 2026
$44.1M
NINDS NIH HHS U19 NS110456
6 · The paper itself

Abstract

BackgroundParkinson's disease (PD) and multiple system atrophy (MSA) are considered α-synucleinopathies, characterized by the presence of pathological α-synuclein (α-syn) aggregates. A positron emission tomography (PET) tracer for imaging α-syn aggregates

Indexed as

alpha-SynucleinAutoradiographyBrainParkinson DiseasePositron-Emission TomographyRadiopharmaceuticalsAnimalsFemaleHumansMaleRatsalpha-SynucleinRadiopharmaceuticalsasyn-44multiple system atrophyParkinson's diseasepositron emission tomographyα-Synuclein

Identifiers

PMID41995458
PMCPMC13224086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.