ArticleMicrobiology spectrum2026
The diagnostic and prognostic utility of blood metagenomic next-generation sequencing for invasive pulmonary aspergillosis.
Yuhui Chen, Xinzhu Tang, Sifen Lu, Liyan Guo, Laduona Wang, Lang Min, Ting Niu, Yongzhao Zhou
Abstract read
In one paragraphArticle in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Yuhui Chen *Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.ORCID 0009-0005-6245-4619 Xinzhu Tang *Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.ORCID 0009-0006-8156-9558 Sifen LuPrecision Medicine Center and Breathing and Comorbidities Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.
Liyan GuoDepartment of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.
Laduona WangDepartment of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.
Lang MinDepartment of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.
Ting NiuDepartment of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0003-1580-1014 Yongzhao ZhouIntegrated Care Management Center, West China Hospital, Sichuan University, Chengdu, China.ORCID 0009-0001-9425-5121 Funding
1.3.5 Project of High Altitude Medicine GYYX24003China Postdoctoral Science Foundation 2025M772028National Key Research and Development Program of China 2022YFC2406804National Natural Science Foundation of China 82370192, U24A20680National Natural Science Foundation of China 82402588Natural Science Foundation of Sichuan Province 2024NSFSC1746the Kunming Medical Joint Special Project of Yunnan Provincial Science and Technology Plan Project 202401AY070001-295the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation GZB20230475the Scientific Research Fund of Yunnan Provincial Department of Education 2024J0304
6 · The paper itselfAbstract
Differentiating invasive pulmonary aspergillosis (IPA) from colonization in patients with IMPORTANCE: First large-scale validation of blood mNGS for invasive pulmonary aspergillosis diagnosis-this study represents the first sizable cohort systematically evaluating blood metagenomic next-generation sequencing (mNGS) for distinguishing invasive pulmonary aspergillosis from colonization, addressing a critical gap in non-invasive diagnostic approaches for critically ill patients. Comprehensive
Indexed as
AspergillusHigh-Throughput Nucleotide SequencingInvasive Pulmonary AspergillosisMetagenomicsAgedbeta-GlucansBiomarkersCoinfectionFemaleGalactoseHumansMaleMannansMiddle AgedPrognosisProteoglycansbeta-GlucansBiomarkersgalactomannanGalactoseMannanspolysaccharide-KProteoglycansbiomarkerinvasive pulmonary aspergillosisMetagenomic next-generation sequencing (mNGS)prognosis
Identifiers
PMID41995327
PMCPMC13228001
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