ArticleJournal of extracellular vesicles2026
In-Solution Characterization of Extracellular Vesicles: A New Approach to Evaluating Antibody Binding and Surface Interactions.
Article in Journal of extracellular vesicles, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Extracellular vesicles (EVs) are emerging as diagnostic and therapeutic agents, yet their nanoscale size limits quantitative single-vesicle analysis of surface epitopes and molecular interactions. Flow-Induced Dispersion Analysis (FIDA) is a microfluidic technique enabling real-time measurement of hydrodynamic size and interaction kinetics using fluorescent ligands without requiring surface immobilization. Here, FIDA was applied to characterize EV-antibody interactions using anti-CD63 antibodies across three EV sources: EVs from genetically engineered HEK cells expressing CD63-eGFP or CD63-NeonGreen-Fc domain (CD63-NG-Fc), and EVs from clonally expanded immortalized mesenchymal stromal cells (ciMSCs). FIDA-measured EV diameter sizes ranged from 40 to 90 nm, compared to 70-200 nm as determined by Nanoparticle Tracking Analysis (NTA), likely reflecting methodological differences or NTA's sensitivity to non-EV particles. CD63-binding EC
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