Using Radial Flow Stream Splitting Columns to Enable High Through-Put High-Performance Liquid Chromatography for the Analysis of Low Molecular Weight Polystyrenes Using UV/Vis and Charged Aerosol Detection.

C E Karlsen, J A Cravino, F Li, A Soliven, R A Shalliker

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Article in Journal of separation science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

C E KarlsenAustralian Centre for Research on Separation Science (ACROSS), School of Science and Health, Western Sydney University, Parramatta, New South Wales, Australia.

J A CravinoAustralian Centre for Research on Separation Science (ACROSS), School of Science and Health, Western Sydney University, Parramatta, New South Wales, Australia.

F LiSchool of Science, Western Sydney University, Parramatta, New South Wales, Australia.

A SolivenSchool of Science, Western Sydney University, Parramatta, New South Wales, Australia.

R A ShallikerAustralian Centre for Research on Separation Science (ACROSS), School of Science and Health, Western Sydney University, Parramatta, New South Wales, Australia.

Funding

Western Sydney University

6 · The paper itself

Abstract

Mass-based detectors, such as, the charged aerosol detector are limited to relatively low flow rates since the mobile phase needs to be removed prior to the detection source. A new column technology, referred to as radial flow stream splitting (RFS) whereby flow can be separated in the radial cross flow directly within the outlet of the chromatography column, enables separations to be undertaken at high flow rates, with high efficiency, but low volume load to the detector. In this study we show the improvement in the separation performance of low molecular weight polystyrenes using columns fitted with RFS end fittings and dual detection with a charged aerosol detector and a UV detector in parallel. There is a reduction in operation pressure by 30% and then a subsequent increase in analysis time by up to three to fourfold, where the detection source is ordinarily flow rate limited. Subsequently, flow rates up to 8 mL/min were tested with some separations being completed within 4 min.

Indexed as

charged aerosol detectorhigh‐speed separationspolystyrenesradial flow stream splitting

Identifiers

PMID41995223

DOI10.1002/jssc.70421

PMCPMC13088741

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.