Evidence map›Paper›PMID 41995072›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

Influence of Tonsillectomy on Various Disease Outcomes: An Outcome-wide Association Analysis and Mendelian Randomization Analysis.

Junhong Li, Ke Qiu, Ping An, Yuyang Zhang, Ziyan Zhang, Lan Feng, Shuo Li, Yanling Liang, Danni Cheng, Yufang Rao and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Junhong LiDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0001-5039-3664
Ke QiuDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Ping AnDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Yuyang ZhangDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Ziyan ZhangDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Lan FengDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Shuo LiDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Yanling LiangDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Danni ChengDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Yufang RaoDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Wendu PangDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0001-5181-9006
Yao SongDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Minzi MaoDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Tao ShuDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Xiuli ShaoDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Rong YuDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Yongbo ZhengDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Wei XuDepartment of Biostatistics, Princess Margaret Cancer Centre and Dalla Lana School of Public Health, Toronto, ON, Canada.
Yu ZhaoDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Jianjun RenDepartment of Otolaryngology-Head & Neck Surgery, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ImportanceTonsillectomy has long been scrutinized for its potential long-term impacts on health, with conflicting evidence linking it to increased risks of several diseases, such as cancer, psychiatric disorders, and immune dysfunctions.ObjectiveTo comprehensively analyze the effects of tonsillectomy on various disease outcomes.DesignLongitudinal cohort study, 2-sample Mendelian randomization (MR) analysis, and multivariable MR (MVMR) analysis.SettingThe UK Biobank.ParticipantsAll UK Biobank (UKB) participants who did not withdraw from the UKB were included. Individuals diagnosed with benign or malignant tonsil tumors, with conflicting information regarding the timing of tonsillectomy, a history of adenoidectomy without tonsillectomy, and incomplete data on birth year, sex, and ethnic background were excluded.Intervention or exposuresTonsillectomy.Main outcome measuresIncident diseases diagnosed based on International Classification of Diseases diagnostic codes and self-reported doctor-diagnosed disease histories.ResultsTonsillectomy was significantly associated with 17 primary core outcomes (incidence ≥ 1%,

Indexed as

Mendelian Randomization AnalysisTonsillectomyAdultCohort StudiesFemaleHumansMaleMiddle AgedTonsillitisUnited Kingdomage at tonsillectomymultivariable mendelian randomizationoutcome-wide association analysistonsillectomytonsillitis

Identifiers

PMID41995072
PMCPMC13100367

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.