Evidence map›Paper›PMID 41995035›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2026

Sales of cigarettes with WS-3, a synthetic cooling agent, in an area with a menthol cigarette sales prohibition.

Jessica K Pepper, In Heon Lee, Alexander Maki, Taylor Lee, Jonathan Hannings, Apoorva O Rajan-Sharma, Kevin C Frissell, Jennifer K Bernat

Abstract read
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jessica K PepperOffice of Health Communication and Education, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD 20993, United States.ORCID 0000-0002-3019-9052
In Heon LeeOffice of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD 20993, United States.ORCID 0000-0002-4279-8538
Alexander MakiOffice of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD 20993, United States.ORCID 0000-0001-8941-3511
Taylor LeeOffice of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD 20993, United States.ORCID 0009-0007-4869-8937
Jonathan HanningsOffice of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD 20993, United States.ORCID 0009-0007-0648-5394
Apoorva O Rajan-SharmaOffice of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD 20993, United States.ORCID 0009-0002-3395-5500
Kevin C FrissellOffice of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD 20993, United States.ORCID 0000-0002-3578-1156
Jennifer K BernatOffice of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD 20993, United States.ORCID 0000-0003-0096-0987

Funding

Center for Tobacco Products (CTP)Food and Drug Administration (FDA)
6 · The paper itself

Abstract

introductionThe synthetic cooling agent WS-3 (N-ethyl-p-menthane-3-carboxamide) elicits a cooling sensation without a minty taste. In areas with menthol cigarette sales prohibitions, such as California, tobacco companies have marketed cigarettes with WS-3 as alternatives to menthol cigarettes. We examined sales of cigarettes with WS-3 in NielsenIQ's Retail Measurement Services Pacific division, which includes the state of California.

methodsWith NielsenIQ data, we estimated sales of cigarettes with WS-3 from June 2022 to March 2024. We compared the NielsenIQ Pacific division, which includes California and two less populous states (Washington and Oregon), to all other divisions combined. Within the Pacific division, we compared trends in sales of cigarettes with WS-3 to menthol cigarettes.

resultsIn our study period, cigarettes with WS-3 appeared in the NielsenIQ Pacific division approximately 2 weeks before the implementation of California's menthol cigarette prohibition in December 2022 and did not appear elsewhere in substantive quantities (>5 cartons) until Spring 2023. Most (87.0%) sales of cigarettes with WS-3 during the study period occurred in the Pacific division, peaking near 19 000 weekly carton sales. Weekly sales of Pacific division menthol cigarettes dropped by more than 100 000 cartons in 2 months after California's prohibition.

conclusionIn the Pacific division, California's menthol cigarette prohibition appears to have moderately reduced sales of menthol cigarettes and spurred sales of cigarettes with WS-3. Observationally, these sales data suggest that cigarettes with WS-3 only partially displaced the declining sales of menthol cigarettes. Future research could examine reasons for and experiences using cigarettes with WS-3. IMPLICATIONS: Tobacco companies explicitly marketed cigarettes with the synthetic cooling agent WS-3 as replacements for menthol cigarettes. Sales data from NielsenIQ's Pacific division suggest that California's menthol cigarette prohibition may have reduced sales of menthol cigarettes and spurred the introduction of cigarettes with WS-3 into the marketplace. The findings suggest that sales of cigarettes with WS-3 did not fully offset the decrease in menthol cigarette sales.

Indexed as

CommerceMentholTobacco IndustryTobacco ProductsCaliforniaHumansOregonWashingtonMentholcigarettementholsales data

Identifiers

PMID41995035
PMCPMC13500345

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.