ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Associations of
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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- Update ofAssociations of2025
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33 authors.
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Abstract
introductionWe examined neurofibrillary tangle (NFT) pathology using 18F-RO-948 tau positron emission tomography (PET) in cognitively unimpaired individuals and its associations with amyloid plaques, fluid biomarkers, and cognition in early preclinical Alzheimer's disease (AD).
methodsWe analyzed 97 participants from the ALFA+ cohort with tau and amyloid PET, magnetic resonance imaging, fluid biomarkers (cerebrospinal fluid [CSF]/plasma), and cognitive data. Braak staging was applied, and correlations with biomarkers and cognitive measures were assessed. Receiver operating characteristic analyses evaluated biomarker performance in predicting tau PET positivity
resultsCSF and plasma tau phosphorylated at threonine 217 (p-tau217) showed the strongest correlation with early Braak I/II tau PET signal (r = 0.58, and r = 0.37, respectively), while plasma p-tau181 and p-tau181/Aβ42 showed moderate associations (r ∼ 0.25). However, positive predictive values were low (PPV = 0.09-0.33). DISCUSSION:
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