Evidence map›Paper›PMID 41994945›Full record

ArticleArchiv der Pharmazie2026

Design, Synthesis and Evaluation of Anticancer Potential of Novel Pyrrolopyrazines Against Glioblastoma: Mechanistic Details and In Vivo Safety Analysis.

Ayşe Usta, Burak Kuzu, Meltem Tan-Uygun, Veysel Yüksek, M Edip Akyol, Nurettin Menges

Abstract read
In one paragraph

Article in Archiv der Pharmazie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayşe UstaDepartment of Chemistry, Faculty of Science, Van Yüzüncü Yil University, Van, Türkiye.ORCID https://orcid.org/0000-0002-5522-3469
Burak KuzuDepartment of Pharmaceutical Chemistry, Van Yüzüncü Yil University, Van, Türkiye.ORCID https://orcid.org/0000-0002-7305-7177
Meltem Tan-UygunDepartment of Pharmaceutical Chemistry, Van Yüzüncü Yil University, Van, Türkiye.
Veysel YüksekDepartment of Medical Laboratory, Özalp Vocational High School, Van Yüzüncü Yıl University, Van, Türkiye.ORCID https://orcid.org/0000-0001-7432-4989
M Edip AkyolDepartment of Neurosurgery, Faculty of Medicine, Van Yüzüncü Yıl University, Van, Türkiye.
Nurettin MengesScientific Research and Application Center (BITAM), Necmettin Erbakan University, Konya, Türkiye.

Funding

Necmettin Erbakan Üniversitesi 2217MER03007Yuzuncu Yil Üniversitesi FBA-2022-9902
6 · The paper itself

Abstract

A protocol through propargyl moiety on pyrrole ring cyclization with ammonium acetate was demonstrated. With this protocol, 11 pyrrolo[1,2-a]pyrazine derivatives were synthesized, and their antiproliferative activity against the U87MG glioblastoma cell line was evaluated. Among the synthesized compounds, a naphthyl-substituted derivative (3g) exhibited the most potent in vitro activity with an IC

Indexed as

Antineoplastic AgentsBrain NeoplasmsDrug DesignGlioblastomaPyrazinesPyrrolesAnimalsApoptosisCell Line, TumorCell ProliferationDose-Response Relationship, DrugHumansInhibitory Concentration 50MaleMiceMolecular StructureAntineoplastic AgentsPyrazinesPyrrolesbiological activityglioblastomapharmacokineticpyrrolopyrazinesstructure‐activity relationship

Identifiers

PMID41994945
PMCPMC13088225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.