ReviewChemical record (New York, N.Y.)2026
Sustainable Synthesis and Biological Aspects of Pyrrolobenzodiazepine Derivatives: An Insight Into Current Developments, Structure-Activity Relationships, and Clinical Studies.
Review in Chemical record (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Sustainable Synthesis and Biological Aspects of Pyrrolobenzodiazepine Derivatives: An Insight Into Current Developments, Structure-Activity Relationships, and Clinical Studies.Chemical record (New York, N.Y.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyrrolobenzodiazepine is tricyclic ring system containing five-, six-, and seven-membered nitrogen heterocycles in the molecular framework. This is a privileged pharmacophore found in pharmaceutical drugs and natural products. However, researchers worldwide are exploring green synthetic methods to develop novel bioactive agents to curb undesirable health effects in humans and aquatic animals. In view of this, various sets of pyrrolobenzodiazepines were synthesized by modulating the ring position or by adding other pharmacophores to enhance the molecules' efficacy. This review is primarily concerned with retrosynthetic, functionalization, and green synthesis of pyrrolobenzodiazepines (1965-2025), followed by an in-depth discussion of their various biological properties, highlighting structure-activity relationships, molecular docking, and in vitro and in vivo studies on pyrrolobenzodiazepines. This review provides an overview of the synthesis, structural characteristics, and diverse spectrum of biological properties, which will surely open a new window for the design and development of potent pyrrolobenzodiazepine-based drugs in future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.