Evidence map›Paper›PMID 41994851›Full record

ArticleACS chemical biology2026

Design, Synthesis, and Application of Sulfonium Diazo Probes for Red-Light Photocatalytic Proximity Labeling.

Feifei Tong, Hong Kai Ng, Ciaran P Seath

Abstract read
In one paragraph

Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Feifei TongWertheim UF Scripps Institute, Jupiter, Florida 33418, United States.ORCID 0009-0003-6872-7177
Hong Kai NgWertheim UF Scripps Institute, Jupiter, Florida 33418, United States.
Ciaran P SeathDepartment of Chemistry, Wertheim UF Scripps Institute, Jupiter, Florida 33418, United States.ORCID 0000-0002-6774-128X

Funding

Photoproximity labeling as a tool for epigenetic drug discoveryR35GM150765 · NIGMS · UNIVERSITY OF FLORIDA · PI Ciaran Seath · 2023 to 2026
$1.9M
Vanquish Neo UHPLC for The Wertheim UF Scripps InstituteS10OD036363 · OD · UNIVERSITY OF FLORIDA · PI TSAPRAILIS, GEORGE · 2024 to 2024
$93k
NIGMS NIH HHS R35 GM150765NIH HHS S10 OD036363
6 · The paper itself

Abstract

Photocatalytic proximity labeling has become a versatile tool for probing biomolecular interactions, with growing interest in longer-wavelength activation, owing to its biocompatibility with various tissue types. Despite recent advances, highly efficient and residue-agnostic labeling systems operating under such conditions remain underdeveloped. Herein, we report the development of a novel labeling probe incorporating an α-sulfonium diazo aryl ketone (sulfonium diazo aryl ketone (SDAK)) scaffold as the reactive warhead, together with a terminal alkyne as the bioconjugation handle. Upon activation by chlorin e6 under red-light irradiation, the SDAK probe enables robust in vitro protein labeling as well as effective mapping of cellular target microenvironments with good spatial and temporal control, providing a foundation for future applications in complex biological contexts.

Indexed as

Azo CompoundsSulfonium CompoundsCatalysisChlorophyllidesHumansPhotochemical ProcessesPorphyrinsRed LightStaining and LabelingAzo CompoundsChlorophyllidesphytochlorinPorphyrinsSulfonium Compounds

Identifiers

PMID41994851
PMCPMC13312234

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.