ReviewCureus2026
Bibliometric Analysis on Enamel Remineralization Agents.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental caries remains a major global oral health concern, affecting almost 2.5 billion people. While restorative treatments remain widely used, modern dentistry increasingly focuses on preventive and minimally invasive approaches that strengthen the natural process of enamel remineralization. A comprehensive literature search was conducted in PubMed for enamel remineralization agents from 2015 to 2025. Clinical trials, randomized controlled trials, systematic reviews, and meta-analyses published in English were included. After screening, 153 publications were retained. RStudio (Biblioshiny package for the Bibliometrix tool, Posit Software, Boston, MA) was used to evaluate publication trends, citation impact, keyword structure, and collaboration networks. A total of 153 publications from 68 sources were identified, contributed by 700 authors, with an average annual growth rate of 10.65% and a mean document age of 4.58 years. Two waves of research activity were observed, with fluoride and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) dominating earlier years and biomimetic agents emerging more recently. This bibliometric mapping reveals enamel remineralization research as a field characterized by steady growth, global collaboration, and diversification of agent types. Fluoride and CPP-ACP continue to anchor the evidence base, while nanohydroxyapatite, bioactive glass, peptides, and natural products are emerging as promising contenders, driving the second wave of publications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.