ArticleCureus2026
Primary Anal Squamous Cell Carcinoma With Metastasis to the Brain Presenting As Stroke-Like Symptoms in a 27-Year-Old Patient.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Metastatic squamous cell carcinoma (SCC) with spread to the brain is a rare entity in primary anal SCC. These findings are especially unusual in a young, HIV-negative patient. We present a case of a 27-year-old woman with metastatic SCC of the anus, previously treated with pelvic radiation and chemotherapy, who presented with acute right-sided weakness mimicking stroke-like symptoms. Neuroimaging revealed multifocal bilateral enhancing lesions consistent with metastatic brain disease. Symptoms resolved following treatment of the vasogenic edema secondary to brain metastasis. This case highlights the unique finding of primary anal SCC with metastasis to the brain in a young, HIV-negative, human papillomavirus type 16 (HPV 16)-positive patient. It further underscores the importance of preventative care with HPV vaccinations to prevent HPV 16 and 18, as well as brain imaging to rule out intracranial metastases in patients with malignancies presenting with new neurological deficits.
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