Evidence map›Paper›PMID 41994716›Full record

ArticleCureus2026

A Case of Constipation During Cobenfy Therapy and a Constipation Prevention Protocol.

Evaristus C Ezema, Amir Meftah, Bashir Aribisala, Satwant Singh, Tania Sultana, Jude Beauchamp, Uchenna Ezenagu, Thant Htet, Tolu Olupona

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Evaristus C EzemaPsychiatry, Interfaith Medical Center, Brooklyn, USA.
Amir MeftahPsychiatry and Behavioral Sciences, Interfaith Medical Center, Brooklyn, USA.
Bashir AribisalaPsychiatry and Behavioral Sciences, Interfaith Medical Center, Brooklyn, USA.
Satwant SinghPsychiatry and Behavioral Sciences, Interfaith Medical Center, Brooklyn, USA.
Tania SultanaPsychiatry and Behavioral Sciences, Interfaith Medical Center, Brooklyn, USA.
Jude BeauchampPsychiatry and Behavioral Sciences, Interfaith Medical Center, Brooklyn, USA.
Uchenna EzenaguPsychiatry and Behavioral Sciences, Interfaith Medical Center, Brooklyn, USA.
Thant HtetPsychiatry and Behavioral Sciences, Interfaith Medical Center, Brooklyn, USA.
Tolu OluponaPsychiatry and Behavioral Sciences, Interfaith Medical Center, Brooklyn, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cobenfy is a new medication for the treatment of schizophrenia. It consists of a muscarinic agonist called xanomeline and a muscarinic antagonist called trospium. However, the associated gastrointestinal side effects, especially constipation, have a potential effect on compliance. Currently, there is no widely standardized constipation prevention protocol during Cobenfy therapy. We present a case of constipation during the treatment of schizoaffective disorder with Cobenfy in a middle-aged female. We conducted a literature review on Cobenfy therapeutic management strategies and provide constipation prevention strategies.

Indexed as

cobenfyconstipationconstipation prevention protocolpreventionprotocol

Identifiers

PMID41994716
PMCPMC13081047

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.