ArticleCureus2026
When Thiamine Is Not the Answer: Sporadic Creutzfeldt-Jakob Disease Mimicking Wernicke's Encephalopathy.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creutzfeldt-Jakob disease (CJD) is a rare and rapidly progressive neurodegenerative disorder caused by the accumulation of misfolded prion proteins, resulting in neuronal damage. It can present with symptoms that mimic other neurological conditions, which can complicate early diagnosis. We report a case of a 58-year-old male who presented with cognitive decline, motor dysfunction, and behavioral changes following alcohol cessation, initially resembling Wernicke's encephalopathy. As his condition progressed, he developed nonconvulsive status epilepticus, and subsequent diagnostic workup demonstrated cortical diffusion restriction on MRI together with a positive real-time quaking-induced conversion (RT-QuIC) assay and elevated cerebrospinal fluid (CSF) 14-3-3 protein levels, confirming the diagnosis of CJD. This report highlights the diagnostic difficulties associated with prion diseases, where early symptoms may overlap with more treatable neurological conditions, and underscores the importance of considering prion disease in cases of rapidly progressive dementia that do not respond to thiamine therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.