ArticleFrontiers in oncology2026
Oropharyngeal cancer mortality in the United States, 1999-2023: a surveillance analysis using CDC WONDER.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oropharyngeal cancer (OPC) is a major head and neck cancer subtype with shifting U.S. epidemiology. We performed a surveillance-style analysis of OPC mortality trends and demographic/geographic disparities, 1999-2023. Methods: OPC mortality (1999-2023) was obtained from CDC WONDER. Age-adjusted mortality rates (AAMRs) were computed by category. Joinpoint regression estimated annual percent change (APC) and average annual percent change (AAPC). Pearson correlation assessed associations between AAMR and structural indicators. Results: From 1999 to 2023, 51,719 OPC-related deaths were recorded. AAMR increased from 0.75 (1999) to 1.17 (2023), with a relatively stable pattern during 1999-2009 (APC = 0.42; 95% CI: -0.47 to 1.32) followed by an increase during 2009-2023 (APC = 3.02; 95% CI: 2.59 to 3.46); the AAPC for 1999-2023 was 1.93 (95% CI: 1.51 to 2.36; Conclusion: OPC mortality increased in the United States from 1999 to 2023, with demographic and geographic disparities. These surveillance findings may support public health monitoring and provide a hypothesis-generating basis for future analytic studies.
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