ReviewFrontiers in neuroscience2026
Therapeutic potential of neuroprotective plant extracts in Parkinson's disease.
Review in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Neuroprotective Potential of Nardostachys jatamansi Extract via Keap1-Nrf2 Pathway Regulation in Parkinson's Disease.Applied biochemistry and biotechnology · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This review aims to summarize the application and mechanisms of plant extracts with neuroprotective effects in Parkinson's disease (PD), emphasizing their therapeutic potential in PD management. Background: Parkinson's disease is a widespread neurodegenerative disorder, predominantly affecting middle-aged and elderly populations. Characterized by varied etiologies, clinical presentations, and complex pathogenesis, its hallmark symptoms include tremor and bradykinesia. Despite the availability of limited pharmacological treatments, current approaches primarily focus on symptom management rather than modifying disease progression. Recent research have increasingly investigates the use of neuroprotective plant extracts, which have shown demonstrating promising therapeutic effects, garnering significant attention in the field. Methods: A systematic review was conducted on preclinical and clinical studies published from 2000 to 2025, sourced from PubMed, ScienceDirect, Google Scholar, and China National Knowledge Infrastructure (CNKI), to evaluate the effects of neuroprotective plant extracts in PD treatment. Results: The review reveals that plant extracts with neuroprotective properties exert anti-PD effects through mechanisms including antioxidant and anti-inflammatory actions, inhibition of α-synuclein (α-syn) aggregation, enhancement of dopaminergic neuron survival, and restoration of synaptic function. Conclusion: This review outlines research directions for the development of neuroprotective plant extracts as novel PD therapies, suggesting their potential as complementary treatments alongside conventional pharmacological interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.